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【文摘发布】MRI预测轻度认知功能损伤
Auther：van de Pol LA, Korf ES, van der Flier WM, Brashear HR, Fox NC, Barkhof F, Scheltens P.
Department of Neurology, Alzheimer Centre, VU Medical Centre, Vrije Universiteit Amsterdam, De Boelelaan, 1117, PO Box 7057, 1007 MB Amsterdam, the Netherlands. L.vandepol@vumc.nl.
Resource:Arch Neurol. 2007 Jul;64(7):1023-8.
Abstract：OBJECTIVES: To describe magnetic resonance imaging characteristics in a large sample of subjects with mild cognitive impairment (MCI) and to investigate associations between these characteristics and cognition. DESIGN: Cohort study. SETTING: Baseline data of a randomized, double-blind, placebo-controlled clinical trial of galantamine in MCI (Trial Registration: clinicaltrials.gov Identifier: NCT00236574). Patients Included in the study were 896 subjects with MCI (age [mean +/- SD], 70 +/- 9 years; 54% women) with available clinical and magnetic resonance imaging data. MAIN OUTCOME MEASURES: Neuropsychology: Alzheimer Disease Assessment Scale, cognitive subscale, MCI version, assessing global cognition; delayed recall on the New York University Paragraph Recall Test, assessing episodic memory; and Digit Symbol Substitution Test, assessing executive function. Neuroimaging: Medial Temporal Lobe Atrophy (MTA) Rating Scale (0-4) and Age-Related White Matter Changes Scale (0-30), assessing white matter hyperintensities (WMHs); and lacune counts. RESULTS: Median MTA score was 2 (range, 0-4), and mean (+/- SD) Age-Related White Matter Changes Scale score 6.0 (+/- 4.7). Lacunes were present in 33% of subjects. In unadjusted models, increasing MTA and WMHs were associated with poorer performance on all cognitive tests, and lacunes with poorer performance on the Alzheimer Disease Assessment Scale, cognitive subscale, MCI version, and the Digit Symbol Substitution Test. In multivariable models, including magnetic resonance imaging measures simultaneously, MTA remained a predictor of cognition, whereas WMH had no independent predictive value. There was an interaction between MTA and lacunes: the strength of the association with the Digit Symbol Substitution Test increased with decreasing MTA. CONCLUSIONS: Medial temporal lobe atrophy seems to be a more important predictor of cognition than small-vessel disease in MCI. Lacunes were associated with performance on the Digit Symbol Substitution Test, especially in subjects with milder MTA. Although WMHs were prevalent and associated with cognition in unadjusted analyses, there was no discernible association between WMHs and the cognitive measures in this study after adjustment for age.
PMID: 17620494 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title：Magnetic resonance imaging predictors of cognition in mild cognitive impairment.
MRI预测轻度认知功能损伤
Auther：van de Pol LA, Korf ES, van der Flier WM, Brashear HR, Fox NC, Barkhof F, Scheltens P.
Department of Neurology, Alzheimer Centre, VU Medical Centre, Vrije Universiteit Amsterdam, De Boelelaan, 1117, PO Box 7057, 1007 MB Amsterdam, the Netherlands. L.vandepol@vumc.nl.
作者单位：荷兰阿姆斯特丹自由大学医学中心，阿尔茨海默氏症研究中心，神经医学部
Resource:Arch Neurol. 2007 Jul;64(7):1023-8.
摘要来源：神经病学文献集2007年7月
Abstract：OBJECTIVES: To describe magnetic resonance imaging characteristics in a large sample of subjects with mild cognitive impairment (MCI) and to investigate associations between these characteristics and cognition.
目的：观察大量的具有轻度认知功能损伤（MCI）的研究对象在进行磁共振（MRI）检查时的特征，研究这些特征和认知功能之间的联系。
DESIGN: Cohort study.
研究设计：队列研究。
SETTING: Baseline data of a randomized, double-blind, placebo-controlled clinical trial of galantamine in MCI (Trial Registration: clinicaltrials.gov Identifier: NCT00236574). Patients Included in the study were 896 subjects with MCI (age [mean +/- SD], 70 +/- 9 years; 54% women) with available clinical and magnetic resonance imaging data.
设置：基线数据经过随机化处理，双盲地分为安慰剂对照组与加兰他敏临床试验组。研究对象是896个患MCI的个体（年龄[平均数+/-方差]为70+/-9；女性比例为54%），都可以进行有效的临床干预和MRI数据的收集。
MAIN OUTCOME MEASURES: Neuropsychology: Alzheimer Disease Assessment Scale, cognitive subscale, MCI version, assessing global cognition; delayed recall on the New York University Paragraph Recall Test, assessing episodic memory; and Digit Symbol Substitution Test, assessing executive function. Neuroimaging: Medial Temporal Lobe Atrophy (MTA) Rating Scale (0-4) and Age-Related White Matter Changes Scale (0-30), assessing white matter hyperintensities (WMHs); and lacune counts.
结果评估标准：神经心理学方面：评估整体认知功能使用了阿尔茨海默氏症评估量表－认知功能（ADAS－Cog）子量表的MCI标准；评估事件记忆能力使用了纽约大学段落回忆测试；评估执行功能使用了数字－符号替换测试。神经影像学方面：评估白质高信号和陷窝计数使用了内侧颞叶萎缩（MTA）等级量表（0－4分）、年龄相关的白质改变量表（0－30分）。
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作者:admin@医学,生命科学 2011-03-12 23:56
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