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【medical-news】偏头痛患者耳蜗损伤常见
NEW YORK (Reuters Health) Apr 11 - Otoacoustic emission testing, which allows monitoring of minute changes in cochlear status, shows dysfunction of cochlea and cochlear efferents in patients with migraine, Turkish researchers report in the April issue of Cephalalgia.
"We unraveled a mechanism that leads to problems with discrimination of tones and lateralization of sound, particularly in a noisy environment, in patients with migraine," lead investigator Dr. Hayrunnisa Bolay told Reuters Health.
"This novel finding," she added, "could be one of the mechanisms underlying increased sensitivity and discomfort to auditory stimuli in migraineurs."
Dr. Bolay and colleagues at Gazi University Hospitals, Ankara, conducted otoacoustic emission and other testing in both ears of 53 patients with migraine and 41 controls. Both groups showed normal distortion product otoacoustic emission functioning of the inner ear at frequencies between 1 and 4kHz.
Among other findings were that in controls, the mean amplitudes of transiently evoked otoacoustic emissions showed a significant decrease in response to contralateral sound stimulus. However, this was not the case in the migraineurs.
"The data," continued Dr. Bolay, "provide evidence for subclinical nervous system abnormality that is widely distributed from the cerebral cortex to the neuromuscular junction, and would probably be a characteristic underlying susceptibility to migraine attacks."
"I think," she concluded, that "dysfunctional central mechanisms modulating the cochlear activity demonstrate another aspect of the migrainous brain in handling sensory signals."
http://www.medscape.com/viewarticle/572907
screen.width-333)this.width=screen.width-333" width=450 height=298 title="Click to view full 200612985153121.jpg (450 X 298)" border=0 align=absmiddle> 我已认领 偏头痛患者的耳蜗机能障碍
纽约（路透社健康报）在4月11日的耳声发射试验中，在允许耳蜗形态在瞬间监测有改变的情况下，发现
了在偏头痛患者存在着耳蜗机能障碍及耳蜗传出神经受阻。土耳其研究者在四月份发表的有关偏头痛报道
中提到
“我们阐明了一个的机制，它导致了中毒和单侧声音的传导，特别是对处于噪音环境下的偏头痛患者”首席
研究者"哈瑞萨博士告诉路透社的记者。
“这个最新发现”她强调,“可以成为导致偏头痛患者过于敏感和不良听觉刺激的潜在诱发机制。”
波利博士，与他在位于土耳其首都的Gazi大学医院的同仁，共通对53位偏头痛患者及41位正常者的双耳
进行了耳声发射及其他实验。两组都出现了正常畸变的产物，耳声发射试验检测内耳功能的频率在1-4千
赫兹之间。
正常组的其他发现中表明，瞬间耳声发射的变动在声音的刺激下有一个明显的降低过程，但是这在偏头痛
患者中并不存在。
这个数据，波利博士继续说，对于圣经系统的亚临床症型提供了一个依据。在大脑皮层的神经肌肉接头处
广泛分布，可能成为偏头痛损伤的一个易感因素。
“我认为”，他继续说，“中心机制就是而耳蜗活动是偏头痛患者的另一个敏感症候。” [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-12 17:14
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