主页 > 医学前沿 >
【medical-news】乙肝病毒的基因型影响肝癌的发生
Infection with hepatitis B virus (HBV) causes liver cancer in some individuals, but not all strains of the virus are associated with the same degree of risk, according to a study published in the August 12 online issue of the Journal of the National Cancer Institute. If confirmed, the newly reported data could help target chemoprevention strategies in the future.
Researchers have previously identified eight genotypes of HBV and a variety of mutations in two regions of the viral genome, referred to as the precore and the basal core promoter. It was not known the extent to which different HBV genotypes or mutations are associated with the risk for liver cancer, which is also called hepatocellular carcinoma.
To find out, Chien-Jen Chen, Sc.D., of the Academia Sinica in Taipei, Taiwan, and colleagues characterized the viral DNA from 2,762 Taiwanese individuals who were infected with the virus but had not been diagnosed with liver cancer at the time of blood collection, which occurred during 1991 and 1992.
After a total follow-up of 33,847 person-years, 153 of these subjects have been diagnosed with liver cancer. HBV genotype C and a particular mutation in the basal core promoter (A1762T/G1764A) were associated with increased risk of liver cancer, while a mutation in the precore region (G1896A) was associated with a decrease in risk.
These data may help identify individuals "who are at an increased risk for liver disease progression and would therefore potentially benefit from early interventions, such as reg¬ular screening to detect disease progression, and treatment," the authors write.
In an accompanying editorial, Josep Llovet, M.D., of Mount Sinai School of Medicine in New York and Anna Lok, M.D., of the University of Michigan Medical Center in Ann Arbor review the previously known risk factors for liver cancer, prevention strategies to reduce the risk of HBV infection, and treatments for individuals who have already developed liver cancer.
"One of the main challenges is to determine whether secondary prevention can be accomplished with new antiviral therapies for HBV infection," the editorialists write. When secondary prevention strategies are tested in large randomized trials, patients should be stratified by known risk factors, including viral genotype and mutations. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Hepatitis B Genotypes And Mutants May Influence Liver Cancer Risk
乙肝病毒的基因型影响肝癌的发生率 好好学学 M.D=硕士？Anna Lok s 美籍华人，美国肝病研究学会AASLD中心专家，美国2007慢乙肝管理指南的主要执笔者。 person-years=patient*year（from fore-investigation to recent-investigation）
gf60810 wrote:
M.D=硕士？Anna Lok s 美籍华人，美国肝病研究学会AASLD中心专家，美国2007慢乙肝管理指南的主要执笔者。
孔方兄 wrote:
person-years=patient*year（from fore-investigation to recent-investigation）
After a total follow-up of 33,847 person-years,应该是在随访了33847人年后。person-years (人年）是流行病统计学中的概念。研究中通常用近似法计算人年，即平均人数乘以观察年数得到总人年数。在看这篇文章的前一部分colleagues characterized the viral DNA from 2,762 Taiwanese individuals who were infected with the virus but had not been diagnosed with liver cancer at the time of blood collection, which occurred during 1991 and 1992.看出其研究对象是1991年到1992年期间2762个感染了乙肝病毒但没有被诊断肝癌的病人。可知这是在随访了33847人年后，2762人中有153名患者发生了肝癌！luob04 wrote:
After a total follow-up of 33,847 person-years,应该是在随访了33847人年后。person-years (人年）是流行病统计学中的概念。研究中通常用近似法计算人年，即平均人数乘以观察年数得到总人年数。在看这篇文章的前一部分colleagues characterized the viral DNA from 2,762 Taiwanese individuals who were infected with the virus but had not been diagnosed with liver cancer at the time of blood collection, which occurred during 1991 and 1992.看出其研究对象是1991年到1992年期间2762个感染了乙肝病毒但没有被诊断肝癌的病人。可知这是在随访了33847人年后，2762人中有153名患者发生了肝癌！
学习学习 需要好好努力治疗乙肝 ~15年，6%HCC,估计是用药的吧，因为能够被医院跟踪。
现在缺的是没有用药的HCC概率。
如果代表台湾的话，HBV携带率达到15%左右。
此外，变异相关的癌变增量在3倍，奇怪的是，摘要里说：G1896A变异反而与HCC负相关，这和我听说的不同。是不是G1896A会导致HBcAg检测不到？ 学习了。基因分型诊断的价值得到了很好的体现。 [标签:content1][标签:content2]阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-03-12 05:14
医学,生命科学网