主页 > 医学前沿 >
【文摘发布】肺鳞状细胞癌的基因表达提示淋巴
Copyright ©ERS Journals Ltd 2007
Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement
J. E. Larsen1,2, S. J. Pavey2,3, R. Bowman2, I. A. Yang1,2, B. E. Clarke4, M. L. Colosimo1, N. K. Hayward2,3 and K. M. Fong1,2
1 Depts of Thoracic Medicine and, 4 Pathology, The Prince Charles Hospital, Brisbane, 2 School of Medicine, University of Queensland, and 3 Human Genetics Laboratory, Queensland Institute of Medical Research, Herston, Australia.
CORRESPONDENCE: J. E. Larsen, Dept of Thoracic Medicine, The Prince Charles Hospital, Brisbane, 4032, Australia. Fax: 61 731394957. E-mail: Jill_E_Larsen@health.qld.gov.au
Keywords: Expression profiling, nodal disease, nonsmall cell lung carcinoma, squamous cell
Received: December 11, 2006
Accepted March 14, 2007
Tumour, node, metastasis staging is essential for lung cancer management. However, similarly staged cancers may have markedly different prognoses, indicating that stage cannot completely explain tumour behaviour. While ipsilateral hilar node involvement is designated N1, the current authors hypothesised that primary tumours involving nodes by direct extension are biologically distinct from those involving nodes through lymphatic metastasis.
Microarrays were used to investigate the gene expression profiles of 59 primary lung squamous cell carcinomas, comparing N0 tumours (n = 35), N1 tumours by direct extension (N1d; n = 8), and N1/N2 tumours by lymphatic metastasis (N1/N2m; n = 16).
Hierarchical clustering using 125 genes differentially expressed between N0 and N1/N2m tumours found N1d tumours clustered with N0 tumours. Class prediction modelling found the expression profiles of all eight N1d tumours were more similar to N0 than to N1/N2m tumours.
The present study demonstrates for the first time that N1 tumours directly invading hilar nodes are genomically different to those that metastasise via lymphatics. Independent reports suggest that tumours with direct, rather than metastatic node involvement have better outcomes. Consequently, the data suggest that there is a need to re-evaluate the N1 staging definition in lung cancer. This is relevant for prognosis prediction and also for clinical management, particularly in selecting those patients most likely to benefit from adjuvant chemotherapy
http://erj.ersjournals.com/cgi/content/abstract/30/1/21 Eur Respir J 2007; 30:21-26
Copyright ©ERS Journals Ltd 2007
Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement
肺鳞状细胞癌的基因表达提示淋巴结受累的方式
J. E. Larsen1,2, S. J. Pavey2,3, R. Bowman2, I. A. Yang1,2, B. E. Clarke4, M. L. Colosimo1, N. K. Hayward2,3 and K. M. Fong1,2
1 Depts of Thoracic Medicine and, 4 Pathology, The Prince Charles Hospital, Brisbane, 2 School of Medicine, University of Queensland, and 3 Human Genetics Laboratory, Queensland Institute of Medical Research, Herston, Australia.
CORRESPONDENCE: J. E. Larsen, Dept of Thoracic Medicine, The Prince Charles Hospital, Brisbane, 4032, Australia. Fax: 61 731394957. E-mail: Jill_E_Larsen@health.qld.gov.au
Keywords: Expression profiling, nodal disease, nonsmall cell lung carcinoma, squamous cell
关键词：表达测序，结节病，非小细胞肺癌，鳞状细胞
Received: December 11, 2006
Accepted March 14, 2007
Tumour, node, metastasis staging is essential for lung cancer management. However, similarly staged cancers may have markedly different prognoses, indicating that stage cannot completely explain tumour behaviour. While ipsilateral hilar node involvement is designated N1, the current authors hypothesised that primary tumours involving nodes by direct extension are biologically distinct from those involving nodes through lymphatic metastasis.
肿瘤的浸润，淋巴结受累，转移分期对于肺癌的治疗是至关重要的。然而，相近分期的癌症的预后却有着显著的差异，提示了分期并不能完全解释肿瘤的行为。当同侧的肺门淋巴结累及时定义为N1，研究者假想直接蔓延累及淋巴结的原发肿瘤的生物学特性和那些通过淋巴途径转移的至淋巴结的肿瘤有本质的差别。
Microarrays were used to investigate the gene expression profiles of 59 primary lung squamous cell carcinomas, comparing N0 tumours (n = 35), N1 tumours by direct extension (N1d; n = 8), and N1/N2 tumours by lymphatic metastasis (N1/N2m; n = 16).
用微数列方法来对59例原发肺鳞状细胞癌的基因表达进行测序，对N0的肿瘤（35例），直接蔓延的N1肿瘤（N1d，8例），和通过淋巴途径转移的N1/N2肿瘤(N1/N2m;16例)进行比较。
Hierarchical clustering using 125 genes differentially expressed between N0 and N1/N2m tumours found N1d tumours clustered with N0 tumours. Class prediction modelling found the expression profiles of all eight N1d tumours were more similar to N0 than to N1/N2m tumours.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-18 17:12
医学,生命科学网