主页 > 医学前沿 >
【文摘发布】胰腺疾病EUS-FNA后高淀粉酶血症的发
Author:Fernández-Esparrach G, Ginès A, García P, Pellisé M, Solé M, Cortés P, Gimeno-García AZ, Sendino O, Navarro S, Llach J, Bordas JM, Castells A.
Resource: Endoscopy. 2007 Aug;39:720-4.
Abstract: BACKGROUND AND STUDY AIM: Acute pancreatitis as a complication of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of pancreatic lesions is rarely observed. However, there is little information on the incidence of hyperamylasemia after EUS-FNA of the pancreas and its clinical significance. This study aimed to supply this lack of information. PATIENTS AND METHODS: Patients who underwent EUS-FNA of a pancreatic lesion between October 2004 and October 2005 were studied prospectively. Exclusion criteria were: platelet count under 50,000/mm (3) and/or prothrombin time < 50 %; (ii) performance of surgery, endoscopic retrograde cholangiopancreatography (ERCP), a percutaneous biopsy attempt, or another invasive procedure within 7 days before EUS-FNA; (iii) lack of informed consent. Serum amylase levels were determined before and 8 and 24 h after the procedure. Hyperamylasemia was defined by amylase levels above 104 UI/L (and higher than baseline levels) 8 h after the procedure. Acute pancreatitis was defined by upper abdominal pain (with or without nausea and/or vomiting) accompanied by elevation of serum amylase or lipase to at least twice baseline levels. RESULTS: A total of 100 patients underwent EUS-FNA of a pancreatic lesion (58 men, 42 women; mean age 60 +/- 13 years). Eleven patients (11 %) showed hyperamylasemia 8 h after the puncture (298 +/- 293 UI/L, range 105 - 1044 UI/L), but only two of them developed acute mild pancreatitis after EUS-FNA. Hyperamylasemia was not related either to the type of lesion (cystic or solid) or to its location, the duration of the procedure, or the number of passes performed. CONCLUSIONS: Pancreatitis after pancreatic EUS-FNA occurs in 2 % of patients, with some more cases of silent hyperamylasemia. This complication may have to be included in the information given to patients for their informed consent.
PMID: 17661248 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 题目:胰腺疾病内镜超声引导下细针抽吸活检（EUS-FNA）后高淀粉酶血症的发生率和临床意义
作者:Fernández-Esparrach G, Ginès A, García P, Pellisé M, Solé M, Cortés P, Gimeno-García AZ, Sendino O, Navarro S, Llach J, Bordas JM, Castells A.
来源: Endoscopy. 2007 Aug;39:720-4.
摘要:背景和研究目的:急性胰腺炎作为胰腺疾病在内镜超声引导下细针抽吸活检（EUS-FNA）的并发症很罕见。然而，有关于胰腺EUS-FNA后高淀粉酶血症发生率和临床意义的信息很少。本研究目的就是提供该部分缺乏的信息。
病人和方法:针对2004年十月至2005年十月间因胰腺疾病实施EUS-FNA的病人的前瞻性研究。淘汰标准： 血小板计数<50,000/mm3 和/或凝血酶原时间<50%; (ii) 在EUS-FNA前的7d内实施过手术、内窥镜逆行胰胆管造影术(ERCP)、经皮活检尝试，或其他侵入性操作者; (iii) 缺乏知情同意书。操作前8h和操作后24h检测血清淀粉酶水平。高淀粉酶血症定义是操作后8h的淀粉酶水平超过104UI/L (或高于基础水平) 。急性胰腺炎定义为上腹痛(有/或无恶心和/或呕吐) ，合并有血清淀粉酶或脂肪酶比基础水平至少升高2倍。
结果: 总共100个病人行胰腺疾病的EUS-FNA (男性58,女性42;平均年龄60 ±13岁)。11个病人(11%)在穿刺后8h证实有高淀粉酶血症(298±293 UI/L,范围105-1044 UI/L),但只有2例发生EUS-FNA后的急性轻型胰腺炎。高淀粉酶血症与病变的类型（囊性或实性）或位置、操作持续时间、或穿刺次数都没有关系。结论:胰腺EUS-FNA后胰腺炎发生于2％的病人，部分更多病例为静息型高淀粉酶血症。该并发症应该被包含在签署知情同意书时告知病人的内容内。
PMID: 17661248 请按文摘类新闻编译格式要求修改译文，详见版内置顶帖。 编译：(354字)
题目:胰腺疾病内镜超声引导下细针抽吸活检（EUS-FNA）后高淀粉酶血症的发生率和临床意义
2007年8月发表《内镜》的一篇文章中，Fernández-Esparrach G等的研究发现，胰腺疾病内镜超声引导下细针抽吸活检（EUS-FNA）后高淀粉酶血症的发生率为11％，胰腺炎为2％。（Endoscopy. 2007,39:720）
在他们的前瞻性研究中，统一病人纳入标准和高淀粉酶血症、急性胰腺炎定义。病人淘汰标准有凝血异常、近期有手术或侵入性操作、缺乏知情同意书。高淀粉酶血症定义是操作后8h的淀粉酶水平超过104UI/L (或高于基础水平) 。急性胰腺炎定义为上腹痛(有/或无恶心和/或呕吐) ，合并有血清淀粉酶或脂肪酶比基础水平至少升高2倍。操作前8h和操作后24h检测血清淀粉酶水平。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-18 05:11
医学,生命科学网