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【文摘发布】立体定向放射外科治疗肺肿瘤的初
Ann Thorac Surg 2007;83:1820-1825
Background: Surgical resection is the standard of care for patients with resectable non-small cell lung carcinoma (NSCLC) or limited pulmonary metastases. Stereotactic radiosurgery (SRS) may offer an alternative option for high-risk patients who are not surgical candidates. We report our initial experience with SRS in the treatment of lung neoplasm.
Methods: Patients who were medically inoperable were offered SRS. Thoracic surgeons evaluated all patients, placed fiducials, and planned treatment in collaboration with radiation oncologists. A median dose of 20 Gy prescribed to the 80% isodose line was administered in a single fraction. The initial response rate, time to progression, and overall survival were evaluated.
Results: During a 2-year period, 32 patients, 27 with NSCLC and 5 with pulmonary metastases, underwent SRS. Fiducial placement resulted in a pneumothorax requiring a pigtail catheter in 9 patients (28%). An initial complete response was observed in 7 patients (22%) and partial response in 10 (31%). Disease was stable in 9 (28%) and progression occurred in 5 patients (16%), with a median time to local progression of 11 months. The median overall survival was 26 months. The probability of 1-year overall survival was 78% (95% confidence interval [CI], 65% to 94%) for the entire group and 91% (95% CI, 75% to 100%) for stage I patients.
Conclusions: Our preliminary experience indicates that SRS has reasonable results in this high-risk group of patients, with pneumothorax being a significant morbidity. Surgery continues to offer the best chance of cure for resectable patients; however, SRS offers an alternative to high-risk patients.
http://ats.ctsnetjournals.org/cgi/content/abstract/83/5/1820 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 初译：
Stereotactic Radiosurgery for the Treatment of Lung Neoplasm: Initial Experience
立体定向放射外科治疗肺肿瘤的初期研究
Ann Thorac Surg 2007;83:1820-1825
Background: Surgical resection is the standard of care for patients with resectable non-small cell lung carcinoma (NSCLC) or limited pulmonary metastases. Stereotactic radiosurgery (SRS) may offer an alternative option for high-risk patients who are not surgical candidates. We report our initial experience with SRS in the treatment of lung neoplasm.
背景：对于可切除的非小细胞肺癌或局限性转移患者而言手术切除是标准的治疗方式。立体定向放射外科(SRS)对于无手术适应症的高风险患者可能提供一种治疗的选择。我们报道了用SRS治疗肺肿瘤的初期经验。 a single fraction
似乎译为单次分割好点。fraction在放射肿瘤学中为分割的意思。 什么是零点指示器，其作用是什么？ placed fiducials
放置零点指示器
改为：置放标记（标记肿瘤位置和范围，用来确定放疗术野）
The median overall survival was 26 months. The probability of 1-year overall survival was 78% (95% confidence interval [CI], 65% to 94%) for the entire group and 91% (95% CI, 75% to 100%) for stage I patients.
患者的总体中位存活率为26个月。对于整个组而言，1年总体存活机率为78％（95%可信区间[CI]为65％至94％），而I期患者为91％（95%可信区间为75％至100％）。
更改为：全体患者中位生存时间26个月。全组病人1年总体生存率为78％（95%可信区间[CI]为65％至94％），而I期患者为91％（95%可信区间为75％至100％）。
Conclusions: Our preliminary experience indicates that SRS has reasonable results in this high-risk group of patients, with pneumothorax being a significant morbidity.
结论：我们的主要经验表明SRS在高风险组（因气胸导致显著的死亡率）患者的治疗中可获得合理的治疗结果。
更改为：我们的初步试验显示：SRS治疗这组高风险病人获得了一定的效果，气胸是其显著的并发症。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-16 17:11
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