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【medical-news】新研究：胃食管反流与血压水平呈
"In 2003 we reported reduced stroke mortality among patients with oesophageal columnar epithelium (Barrett's oesophagus), with cerebrovascular deaths in patients with specialized intestinal metaplasia of the oesophagus being half that of the general population," Dr. Roger B. McCorry, of Bolton Hospitals NHS Trust, UK, and colleagues write.
They hypothesized that "the association we observed may be due to individuals with reduced lower oesophageal sphincter pressure, (a risk factor for gastro-oesophageal reflux and Barrett's oesophagus) also having low vascular tone and blood pressure, resulting in reduced stroke risk."
To investigate, the researchers used data from a community-based, randomized controlled trial of eradication of Helicobacter pylori. Of the 4227 subjects with complete data included in the analysis, 107 (2.5%) experienced daily heartburn and 66 (1.6%) experienced daily acid regurgitation.
Mean systolic blood pressure was 4.2 mm Hg lower and mean diastolic blood pressure was 2.1 mm Hg lower in participants with daily acid regurgitation compared to those with less frequent symptoms, the investigators report. No association was observed between daily heartburn and blood pressure.
"We suggest that factors influencing the endogenous production of nitric oxide underlie the observed association between symptoms of gastro-oesophageal reflux and blood pressure," Dr. McCorry and colleagues write. "Confirmation of these findings, and further investigation of the pathophysiological role that NO may play in gastro-oesophageal reflux, and possibly Barrett's oesophagus, are warranted."
BMC Gastroenterology 2008;8. NEW YORK (Reuters Health) May 07 - Patients who experience daily gastric acid reflux have lower blood pressure than those who experience fewer GERD episodes or none, according to study findings published April 15th by BMC Gastroenterology.
纽约（路透社 健康）5月7日——根据4月15日刊登在《BMC Gastroenterology》（《生物医学中心胃肠病学》）的一项研究发现，每天有胃食管返流症状发作的患者比此类事件少或没有的患者血压更低。
"In 2003 we reported reduced stroke mortality among patients with oesophageal columnar epithelium (Barrett's oesophagus), with cerebrovascular deaths in patients with specialized intestinal metaplasia of the oesophagus being half that of the general population," Dr. Roger B. McCorry, of Bolton Hospitals NHS Trust, UK, and colleagues write.
“在2003年我们报道：食管慢性炎伴腺上皮化生的患者卒中死亡率下降，食管肠化生的患者脑血管死亡人数是普通人群的一半，”英联邦博尔顿全民健康医疗服务基金会医院的Roger B. McCorry医生及同事写道。
They hypothesized that "the association we observed may be due to individuals with reduced lower oesophageal sphincter pressure, (a risk factor for gastro-oesophageal reflux and Barrett's oesophagus) also having low vascular tone and blood pressure, resulting in reduced stroke risk."
他们猜测“两者之间的关联可能由于食管括约肌压力更低的个体，（胃食管返流和食管慢性炎伴腺上皮化生的危险因素之一）血管紧张度和血压也低，结果导致卒中的危险下降。”
To investigate, the researchers used data from a community-based, randomized controlled trial of eradication of Helicobacter pylori. Of the 4227 subjects with complete data included in the analysis, 107 (2.5%) experienced daily heartburn and 66 (1.6%) experienced daily acid regurgitation.
研究者收集了以社区群众为基础的幽门螺旋杆菌根除随机对照研究的数据。该研究纳入了数据完整的4227名参与者，107人（2.5％）每天有胃灼热症状，66人（1.6％）每天有胃酸返流症状。
Mean systolic blood pressure was 4.2 mm Hg lower and mean diastolic blood pressure was 2.1 mm Hg lower in participants with daily acid regurgitation compared to those with less frequent symptoms, the investigators report. No association was observed between daily heartburn and blood pressure.
和那些胃酸返流症状发作频率少的人群比较，每天有此类事件发作的参与者平均收缩压下降4.2mmHg、平均舒张压下降2.1mmHg.
"We suggest that factors influencing the endogenous production of nitric oxide underlie the observed association between symptoms of gastro-oesophageal reflux and blood pressure," Dr. McCorry and colleagues write. "Confirmation of these findings, and further investigation of the pathophysiological role that NO may play in gastro-oesophageal reflux, and possibly Barrett's oesophagus, are warranted."
“我们认为影响内源性一氧化氮生成的因素是胃酸返流症状与血压关联的基础，”McCorry医生及同事写道。“证实这些发现，进一步研究一氧化氮作用于食管返流病的可能病理生理机制，或许还包括食管慢性炎伴腺上皮化生，是下一步应当做的。”
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作者:admin@医学,生命科学 2010-11-27 17:11
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