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【文摘发布】尿液浓缩的种族差异：与血压的可
The mechanisms that account for the susceptibility of black individuals to hypertension and their reduced ability to excrete sodium are poorly understood. Vasopressin administration has been shown in healthy humans to delay sodium excretion along with its antidiuretic action. Black individuals have been reported to have higher vasopressin levels than white individuals. Therefore, this study investigated retrospectively 24-h urine volume (V) and urine concentration index (urine-to-plasma ratio of creatinine concentration), as well as their possible relationships with BP, in a cohort of 141 healthy young black and white individuals (18 to 40 y). Black individuals were found to have a significantly lower V and higher urine concentration than white individuals, especially during daytime. In addition, they exhibited a blunted nocturnal fall in fluid and electrolyte excretion and a higher pulse pressure than white individuals. Higher urine concentration and lower V were associated significantly with higher PP (but not with systolic or diastolic BP) in men. These relations remained significant after adjustment for age, body mass index, and sodium and potassium excretion. These results suggest that an enhanced tendency to concentrate urine may delay the excretion of the daily ingested fluid and sodium and may increase pulse pressure in young normotensive individuals. The higher urine concentration that is observed in black individuals (which could represent an adaptation to better water conservation) may participate in their enhanced susceptibility to hypertension. If these results are confirmed in further studies, then vasopressin V2 receptor antagonists might offer a novel antihypertensive strategy, especially in the black population. 尿液浓缩的种族差异：与血压的可能关系
The mechanisms that account for the susceptibility of black individuals to hypertension and their reduced ability to excrete sodium are poorly understood.
导致黑人个体易感高血压及钠排泄能力的减低的机制还不十分清楚。
Vasopressin administration has been shown in healthy humans to delay sodium excretion along with its antidiuretic action.
在健康人中应用血管加压素可以使钠排泄延迟及抗利尿。
Black individuals have been reported to have higher vasopressin levels than white individuals.
据报道，黑人个体比白种人个体有较高的血管加压素水平。
Therefore, this study investigated retrospectively 24-h urine volume (V) and urine concentration index (urine-to-plasma ratio of creatinine concentration), as well as their possible relationships with BP, in a cohort of 141 healthy young black and white individuals (18 to 40 y).
因此，本研究观察了一组141名年轻黑人、白人（18－40岁）的24小尿量，尿浓缩指数（尿血肌酐比），及可能的与血压值的关联。
Black individuals were found to have a significantly lower V and higher urine concentration than white individuals, especially during daytime. In addition, they exhibited a blunted nocturnal fall in fluid and electrolyte excretion and a higher pulse pressure than white individuals.
研究发现黑种人尿量较白种人少，但尿浓缩指数高，这一情况在白天尤为明显。而且，较白种人而言，黑种人夜间水盐代谢下降幅度迟钝，同时伴脉压增高。
Higher urine concentration and lower V were associated significantly with higher PP (but not with systolic or diastolic BP) in men.
在男性中，高浓缩尿及低尿量通常伴有显著的脉压增高（而不是收缩压或舒张压）
These relations remained significant after adjustment for age, body mass index, and sodium and potassium excretion.
在经匹配年龄、体重指数、钠钾排泄等因素后，这些关联性依然显著。
These results suggest that an enhanced tendency to concentrate urine may delay the excretion of the daily ingested fluid and sodium and may increase pulse pressure in young normotensive individuals.
这些结果提示增强的尿液浓缩可能延迟日间饮食吸收的水钠，并可能导致血压正常个体的脉压增高。
The higher urine concentration that is observed in black individuals (which could represent an adaptation to better water conservation) may participate in their enhanced susceptibility to hypertension.
黑人中高尿浓缩能力（可以通过更好的水储留来适应）可能参与了更易感高血压的内在机制。
If these results are confirmed in further studies, then vasopressin V2 receptor antagonists might offer a novel antihypertensive strategy, especially in the black population.
如果这些结果能被将来的研究证实，那么血管加压素V2受体拮抗剂可能将成为新的降压策略，尤其是适用黑人种群。
尿液浓缩的种族差异：与血压的可能关系
导致黑人个体易感高血压及钠排泄能力的减低的机制还不十分清楚。在健康人中应用血管加压素可以使钠排泄延迟及抗利尿。据报道，黑人个体比白种人个体有较高的血管加压素水平。因此，本研究观察了一组141名年轻黑人、白人（18－40岁）的24小尿量，尿浓缩指数（尿血肌酐比），及可能的与血压值的关联。研究发现黑种人尿量较白种人少，但尿浓缩指数高，这一情况在白天尤为明显。而且，较白种人而言，黑种人夜间水盐代谢下降幅度迟钝，同时伴脉压增高。在男性中，高浓缩尿及低尿量通常伴有显著的脉压增高（而不是收缩压或舒张压）在经匹配年龄、体重指数、钠钾排泄等因素后，这些关联性依然显著。这些结果提示增强的尿液浓缩可能延迟日间饮食吸收的水钠，并可能导致血压正常个体的脉压增高。黑人中高尿浓缩能力（可以通过更好的水储留来适应）可能参与了更易感高血压的内在机制。如果这些结果能被将来的研究证实，那么血管加压素V2受体拮抗剂可能将成为新的降压策略，尤其是适用黑人种群。 各位见笑了，自产自销了。
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作者:admin@医学,生命科学 2010-11-23 17:11
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