主页 > 医学前沿 >
【文摘发布】出生时低体重的青年的血糖调整
TITLE: Glucose Regulation in Young Adults with Very Low Birth Weight
AUTHOR: Petteri Hovi, M.D., Sture Andersson, M.D., Ph.D., Johan G. Eriksson, M.D., Ph.D., Anna-Liisa Järvenpää, M.D., Ph.D., Sonja Strang-Karlsson, M.D., Outi Mäkitie, M.D., Ph.D., and Eero Kajantie, M.D., Ph.D.
ABSTRACT
Background The association between small size at birth and impaired glucose regulation later in life is well established in persons born at term. Preterm birth with very low birth weight (<1500 g) is also associated with insulin resistance in childhood. If insulin resistance persists into adulthood, preterm birth with very low birth weight also may be associated with an increased risk of disease in adulthood. We assessed glucose tolerance and insulin sensitivity and measured serum lipid levels and blood pressure in young adults with very low birth weight.
Methods We performed a standard 75-g oral glucose-tolerance test, measuring insulin and glucose concentrations at baseline and at 120 minutes in 163 young adults (age range, 18 to 27 years) with very low birth weight and in 169 subjects who had been born at term and were not small for gestational age. The two groups were similar with regard to age, sex, and birth hospital. We measured blood pressure and serum lipid levels, and in 150 very-low-birth-weight subjects and 136 subjects born at term, we also measured body composition by means of dual-energy x-ray absorptiometry.
Results As compared with the subjects born at term, the very-low-birth-weight subjects had a 6.7% increase in the 2-hour glucose concentration (95% confidence interval [CI], 0.8 to 12.9), a 16.7% increase in the fasting insulin concentration (95% CI, 4.6 to 30.2), a 40.0% increase in the 2-hour insulin concentration (95% CI, 17.5 to 66.8), an 18.9% increase in the insulin-resistance index determined by homeostatic model assessment (95% CI, 5.7 to 33.7), and an increase of 4.8 mm Hg in systolic blood pressure (95% CI, 2.1 to 7.4). Adjustment for the lower lean body mass in the very-low-birth-weight subjects did not attenuate these relationships.
Conclusions Young adults with a very low birth weight have higher indexes of insulin resistance and glucose intolerance and higher blood pressure than those born at term. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 RESOURCE: NEJM，Volume 356:2053-2063 May 17, 2007 Number 20
源自:《新英格兰医学杂志》，356卷:2053-2063，2007年5月17日20号
TITLE: Glucose Regulation in Young Adults with Very Low Birth Weight
标题: 极低出生体重年轻成年人的血糖调节
AUTHOR: Petteri Hovi, M.D., Sture Andersson, M.D., Ph.D., Johan G. Eriksson, M.D., Ph.D., Anna-Liisa Järvenpää, M.D., Ph.D., Sonja Strang-Karlsson, M.D., Outi Mäkitie, M.D., Ph.D., and Eero Kajantie, M.D., Ph.D.
作者: Petteri Hovi, M.D., Sture Andersson, M.D., Ph.D., Johan G. Eriksson, M.D., Ph.D., Anna-Liisa Järvenpää, M.D., Ph.D., Sonja Strang-Karlsson, M.D., Outi Mäkitie, M.D., Ph.D., and Eero Kajantie, M.D., Ph.D.
Background ：The association between small size at birth and impaired glucose regulation later in life is well established in persons born at term. Preterm birth with very low birth weight (<1500 g) is also associated with insulin resistance in childhood. If insulin resistance persists into adulthood, preterm birth with very low birth weight also may be associated with an increased risk of disease in adulthood. We assessed glucose tolerance and insulin sensitivity and measured serum lipid levels and blood pressure in young adults with very low birth weight.
背景：出生时的体型瘦小和今后的血糖调节受损两者之间的联系，在人们出生时就已经完好确立了。 极低体重的早产儿(<1500g),在其童年往往伴随胰岛素抵抗。如果胰岛素抵抗持续到成年， 极低体重早产儿，也可能和成年疾病风险增加相关。 我们评估出生时极低体重的成年人的血糖耐受和胰岛素敏感度及血脂和血压值。
Methods We performed a standard 75-g oral glucose-tolerance test, measuring insulin and glucose concentrations at baseline and at 120 minutes in 163 young adults (age range, 18 to 27 years) with very low birth weight and in 169 subjects who had been born at term and were not small for gestational age. The two groups were similar with regard to age, sex, and birth hospital. We measured blood pressure and serum lipid levels, and in 150 very-low-birth-weight subjects and 136 subjects born at term, we also measured body composition by means of dual-energy x-ray absorptiometry.
方法：我们进行了一个标准的75克口服葡萄糖耐受试验，测量了胰岛素及血糖浓度在120分钟内处于基线时的数值，分别在163名以极低体重出生的年轻成年组(年龄介于 18至27岁)，和169名足月和早产但不瘦小的对照受试组。两组在年龄，性别，和出生的医院相似。我们测量了血压和血脂水平，并对150位极低体重出生者和136位足月出生者，我们还用双能量X线吸收计算法测量了他们身体的组成。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2010-09-26 17:11
医学,生命科学网