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【Diabetes Care】1型糖尿病妇女骨密度自始至终偏低
http://care.diabetesjournals.org/cgi/content/abstract/31/9/1729
OBJECTIVE—Individuals with type 1 diabetes have decreased bone mineral density (BMD), yet the natural history and pathogenesis of osteopenia are unclear. We have previously shown that women with type 1 diabetes (aged 13–35 years) have lower BMD than community age-matched nondiabetic control subjects. We here report 2-year follow-up BMD data in this cohort to determine the natural history of BMD in young women with and without diabetes.
RESEARCH DESIGN AND METHODS—BMD was measured by dual-energy X-ray absorptiometry at baseline and 2 years later in 63 women with type 1 diabetes and in 85 age-matched community control subjects. A1C, IGF-1, IGF binding protein-3, serum osteocalcin, and urine N-teleopeptide were measured at follow-up.
RESULTS—After adjusting for age, BMI, and oral contraceptive use, BMD at year 2 continued to be lower in women 20 years of age with type 1 diabetes compared with control subjects at the total hip, femoral neck, and whole body. Lower BMD values were observed in cases <20 years of age compared with control subjects; however, the differences were not statistically significant. Lower BMD did not correlate with diabetes control, growth factors, or metabolic bone markers.
CONCLUSIONS—This study confirms our previous findings that young women with type 1 diabetes have lower BMD than control subjects and that these differences persist over time, particularly in women 20 years of age. Persistence of low BMD as well as failure to accrue bone density after age 20 years may contribute to the increased incidence of osteoporotic hip fractures seen in postmenopausal women with type 1 diabetes. 这篇居然没人要?
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 骨密度低减将伴随年轻的1型糖尿病妇女终生
OBJECTIVE—Individuals with type 1 diabetes have decreased bone mineral density (BMD), yet the natural history and pathogenesis of osteopenia are unclear. We have previously shown that women with type 1 diabetes (aged 13–35 years) have lower BMD than community age-matched nondiabetic control subjects. We here report 2-year follow-up BMD data in this cohort to determine the natural history of BMD in young women with and without diabetes.
目的:1型糖尿病人普遍有骨密度低减,但导致其骨质疏松的自然病理发展过程和机制仍不明.我们在以前的研究中已经发现1型糖尿病妇女(13-35岁)与社区年龄相匹配的正常人相比骨密度有所降低,在此,我们将报道此研究随后关于年轻糖尿病妇女或非糖尿病妇女2年的骨密度跟踪调查数据,以确定其骨密度自然进展情况.
RESEARCH DESIGN AND METHODS—BMD was measured by dual-energy X-ray absorptiometry at baseline and 2 years later in 63 women with type 1 diabetes and in 85 age-matched community control subjects. A1C, IGF-1, IGF binding protein-3, serum osteocalcin, and urine N-teleopeptide were measured at follow-up.
研究设计和方法:在2年的研究中,共63名1型糖尿病妇女和85名年龄与之相匹配的社区正常妇女参与,通过双能X射线吸光分析法测定骨密度,并检测糖化血红蛋白A1C,胰岛素样生长因子-1,胰岛素样生长因子结合蛋白-3,血清骨钙素，尿N-teleopeptide（才疏学浅，不识正确学名，望方家赐教）。
RESULTS—After adjusting for age, BMI, and oral contraceptive use, BMD at year 2 continued to be lower in women 20 years of age with type 1 diabetes compared with control subjects at the total hip, femoral neck, and whole body. Lower BMD values were observed in cases <20 years of age compared with control subjects; however, the differences were not statistically significant. Lower BMD did not correlate with diabetes control, growth factors, or metabolic bone markers.
结果：经矫正年龄，体重指数，口服避孕药因素,2年后，与对照组相比，20岁的1型糖尿病妇女在整个臀部（髋骨？），股骨颈和全身的骨密度持续下降。与对照组相比，20岁以下的1型糖尿病妇女骨密度仍有所降低，虽然其无统计学差异。骨密度的降低与糖尿病的控制、生长因子和代谢性骨指标无关。
CONCLUSIONS—This study confirms our previous findings that young women with type 1 diabetes have lower BMD than control subjects and that these differences persist over time, particularly in women 20 years of age. Persistence of low BMD as well as failure to accrue bone density after age 20 years may contribute to the increased incidence of osteoporotic hip fractures seen in postmenopausal women with type 1 diabetes.
推论：该研究验证了之前我们提出的关于年轻的1型糖尿病妇女（尤其在20岁以上的妇女中）较之对照组骨密度会有所降低并呈持续发展趋势的可能。在20岁以上的妇女中，持续的骨密度降低和骨密度再生障碍一样，都将增加绝经后1型糖尿病妇女由骨质疏松导致的髋骨骨折之发生率。
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作者:admin@医学,生命科学 2010-11-04 17:11
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