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【drug-news】口服类固醇早期治疗急性坐骨神经痛
Richard L. Holve, MD and Howard Barkan, DrPH
From the Department of Family Medicine, Kaiser Permanente Medical Center, Santa Rosa; and Department of Surgery, Kaiser Permanente Medical Center, Oakland, CA
Correspondence: Corresponding author: Richard Holve, MD, Department of Family Practice, Kaiser Permanente Medical Center, Santa Rosa, CA 95403 (E-mail: Rich.Holve@kp.org)
Objective: Many physicians use prednisone to treat acute sciatica with the hope of speeding recovery. There is little clinical evidence to support this practice. Our objective was to determine whether early administration of oral prednisone affects parameters related to recovery from acute sciatica.
Methods: In this double-blind, controlled clinical trial, 27 patients were sequentially assigned to receive either a 9-day tapering course of prednisone (n = 13) or placebo (n = 14) within 1 week of developing sciatic symptoms. Patients and investigators were blinded to the drug administered. Follow-up assessment was done weekly for 1 month and then monthly for 5 months.
Results: Prednisone and control groups showed no statistically significant differences in physical findings, use of nonsteroidal anti-inflammatory drugs or narcotic medications, or rates of patients returning to work at any time interval studied. Compared with controls, patients who received prednisone had more rapid rates of improvement from baseline in pain, mental well-being, and disability scores. These changes were subtle but statistically significant. Patients who received prednisone tended to receive fewer epidural injections for pain.
Conclusions: Early administration of oral steroid medication in patients with acute sciatica had no significant effect on most parameters studied. It did, however, lead to slightly more rapid rates of improvement in pain, mental well-being, and disability scores. The impact of oral steroids on other outcomes is suggested by this study, but its small sample size limited its statistical power.
http://www.jabfm.org/cgi/content/short/21/5/469
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作者:admin@医学,生命科学 2010-11-27 17:11
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