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【medical-news】缺氧可致炎症，从而致病
Study Links Hypoxia and Inflammation in Many Diseases
ScienceDaily (Feb. 18, 2011) — When the body is deprived of oxygen during a major surgery, the kidneys, heart muscles or lungs can be injured as a result. The problem is that lack of oxygen can lead to inflammation.
Yet some athletes deliberately train at high altitude, with less oxygen, so they can perform better. Their bodies adapt to the reduced oxygen.
Now a doctor at the University of Colorado School of Medicine has explored the relationship between lack of oxygen, called hypoxia, and the inflammation that can injure or kill some patients who undergo surgery. In a liver transplant, for example, the surgery and anesthesiology can go perfectly yet the new liver will fail because of hypoxia.
"Understanding how hypoxia is linked to inflammation may help save lives of people who have survived a major surgery only to be faced with potential harm to major organs," says Holger K. Eltzschig, MD, PhD.
Eltzschig's exploration of the relationship between hypoxia and inflammation was published Feb. 17 in the New England Journal of Medicine. His work was supported by more than $1 million from the National Institutes of Health.
Those high-altitude athletes figured into the research. How do their bodies adapt to low levels of oxygen? And how can that information help patients?
The answer appears to lie at the molecular level. The body can signal a helpful response to deal with low oxygen levels. To do so it uses what's called hypoxia-inducible factor (HIF). This is a protein that sends complex signals to help the body defend itself.
Eltzschig says that research now should focus on understanding more about the way these signals function.
"By focusing on the molecular pathways the body uses to battle hypoxia, we may be able help patients who undergo organ transplants, who suffer from infections or who have cancer," says Eltzschig, a professor of anesthesiology, medicine, cell biology and immunology.
"We know the body can do this. Our research goal now is to find out exactly how." [热点资讯]再论转基因水稻,越国计谋的现代版?_经济论坛_天涯社...发表时间：2010-3-23 一个人不能这么笨,去害十几亿人,和十几亿人作对,不会有什么好下场的,真相大白之时,每... 做作业就图多,不用心或者力不从心. 就算现在时不时的我国的生命科学的科研人员把论文...www.tianya.cn/publicforum/c... - 2010-03-25-快照-国家级继续教育项目文件类型:PDF/Adobe Acrobat- 文字版素,从而引起炎症、疼痛和发热;COX-2 在大多数器官不能检出,但在炎症部位的炎症细 胞... 公 司出版,收录了 1989 年以来有关自然科学、工程技术、农业、医药、 经 济管理、教...yxy.hutc.zj.cn/...12233934.pdf-2011-02-02-[热点资讯]再论转基因水稻,越国计谋的现代版? 天涯帖子只看楼主...(1)、与人类生命健康相关的重大科学实验,除了对小鼠的实验外,必须有人类作临床实验.... 很多人因此腹泻,但都被归结为了乳糖不耐受症等疾病,从而掩盖了BT致病的事实. 所以,...www.tianyayidu.com/...2-3.html-2010-03-23-快照-[标签:content2]
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作者:admin@医学,生命科学 2011-02-20 00:03
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