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【bio-news】麻省理工：3－D细胞生长助力药物研发
http://www.sciencedaily.com/releases/2008/12/081218054635.htm
ScienceDaily (Dec. 23, 2008) — MIT engineers have built a device that gives them an unprecedented view of three-dimensional cell growth and migration, including the formation of blood vessels and the spread of tumor cells.
The microfluidic device, imprinted on a square inch of plastic, could be used to evaluate the potential side effects of drugs in development, or to test the effectiveness of cancer drugs in individual patients.
Roger Kamm, MIT professor of biological and mechanical engineering, and his colleagues reported their observations of angiogenesis -- the process by which blood vessels are formed -- in the Oct. 31 online issue of the journal Lab on a Chip.
Microfluidic devices have been widely used in recent years to study cells, but most only allow for the study of cells growing on a flat (two-dimensional) surface, or else lack the ability to observe and control cell behavior. With the new device, researchers can observe cells in real time as they grow in a three-dimensional collagen scaffold under precisely controlled chemical or physical conditions.
Observing angiogenesis and other types of cell growth in three dimensions is critical because that is how such growth normally occurs, said Kamm.
Working with researchers around MIT, Kamm has studied growth patterns of many types of cells, including liver cells, stem cells and neurons. He has also used the device to investigate the pressure buildup that causes glaucoma.
The device allows researchers to gain new insight into cell growth patterns. For example, the researchers observed that one type of breast cancer cell tends to migrate in a uniform mass and induces new capillaries to sprout aggressively toward the original tumor, while a type of brain cancer cell breaks from the primary tumor and migrates individually but does not promote capillary formation.
The system is configured so that researchers can manipulate and study mechanical and biochemical factors that influence cell growth and migration, including stiffness of the gel scaffold, concentration of growth factors and other chemicals, and pressure gradients.
Two or three channels imprinted onto the plastic square contain either a normal cell growth medium or a chemical under study, such as growth factor. Cells growing in the scaffold between the channels are bathed in chemicals from the channels, and the effect of the chemicals can be evaluated based on various measures of cell function.
Kamm and his colleagues first described their microfluidic device in a January 2007 paper in Lab on a Chip. Vernella Vickerman, a graduate student in chemical engineering, and Seok Chung, a postdoctoral fellow in biological engineering, played critical roles in developing the device, Kamm said.
The research was funded by Draper Laboratory.
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Adapted from materials provided by Massachusetts Institute Of Technology.
MIT engineers built a device that gives them an unprecedented view of 3-d cell growth and migration. (Credit: Photo by Donna Coveney)
screen.width-333)this.width=screen.width-333" width=300 height=225 title="Click to view full 081222221539.jpg (300 X 225)" border=0 align=absmiddle> 感觉很有意思，尝试一下。
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 3-D Cell Growth: Engineers' New Microfluidic Device Could Help With Drug Development
三维细胞生长：工程师的新微流体装置可以助力药物开发
http://www.sciencedaily.com/releases/2008/12/081218054635.htm
ScienceDaily (Dec. 23, 2008) — MIT engineers have built a device that gives them an unprecedented view of three-dimensional cell growth and migration, including the formation of blood vessels and the spread of tumor cells.
科学日报（08年12月23号）-美国麻省理工学院的工程师们建立了一个装置，使他们前所未有的看到了三维细胞生长和迁移，包括血管的形成和肿瘤细胞的扩散。
The microfluidic device, imprinted on a square inch of plastic, could be used to evaluate the potential side effects of drugs in development, or to test the effectiveness of cancer drugs in individual patients.
这一印在一平方英寸的塑料板上的微流体装置，可以用来评估开发中的药物的潜在副作用，或者测试单个患者使用抗癌药物的有效性。
Roger Kamm, MIT professor of biological and mechanical engineering, and his colleagues reported their observations of angiogenesis -- the process by which blood vessels are formed -- in the Oct. 31 online issue of the journal Lab on a Chip.
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作者:admin@医学,生命科学 2011-02-18 17:11
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