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【bio-news】科学家发现不同患者对同一剂量药物反
Main Category: Biology / Biochemistry News
Article Date: 18 Jan 2007 - 5:00 PST
Why does the standard dose of certain medications prove dangerously high for some patients and too low to produce beneficial effects in others? Scientists have added a previously unrecognized factor to the list of explanations (such as age, gender, diet and genetics) for this common problem of individual variability in response to drugs.
Jeffrey P. Krise and Ryan S. Funk, at the University of Kansas, are reporting that variations in the body's production of hydrogen peroxide -- believed to serve as a signaling molecule at low levels -- can affect accumulation of drugs inside cells. Their study, which involved cultured human cells and a common anti-cancer drug, is scheduled for the Feb. 5, 2007, issue of the ACS's Molecular Pharmaceutics, a bi-monthly journal.
"The demonstrated correlation between hydrogen peroxide exposure and the concomitant increase in drug accumulation represents a substantial finding," the study reports. "The results suggest that patients experiencing oxidative stress (or an increase in hydrogen peroxide levels) may have an increased response to a given dosage of a drug relative to a patient with decreased oxidative stress, or those patients chronically taking antioxidants [such as vitamins C or E] with their medications. This could be a very important factor in our continued efforts to provide more individualized dosing of drugs."
Hydrogen peroxide's effects could be especially important in about two dozen so-called narrow therapeutic index drugs (such as aminophylline, carbamazepine, lithium carbonate, phenytoin, theophylline and warfarin) for which very small changes in dosage level could cause either subtherapeutic or toxic results, they note.
ARTICLE #3
"Exposure of Cells to Hydrogen Peroxide Can Increase the Intracellular Accumulation of Drugs"
CONTACT:
Jeffrey P. Krise, Ph.D.
The University of Kansas
Lawrence, Kansas
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http://www.medicalnewstoday.com/medicalnews.php?newsid=60892 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Why does the standard dose of certain medications prove dangerously high for some patients and too low to produce beneficial effects in others? Scientists have added a previously unrecognized factor to the list of explanations (such as age, gender, diet and genetics) for this common problem of individual variability in response to drugs.
为什么一些人服用标准剂量药物非常危险,而另一些人则服用较低的剂量却能产生好的药效?科学家对这种不同个体对药物产生不同反应的常见原因中又添加了以前被人们忽略的年龄,性别,饮食和遗传因素.
Jeffrey P. Krise and Ryan S. Funk, at the University of Kansas, are reporting that variations in the body's production of hydrogen peroxide -- believed to serve as a signaling molecule at low levels -- can affect accumulation of drugs inside cells. Their study, which involved cultured human cells and a common anti-cancer drug, is scheduled for the Feb. 5, 2007, issue of the , a bi-monthly journal.
克萨斯大学Jeffrey P. Krise和Ryan S. Funk报道人体低水平可作为信号分子的过氧化氢产生水平的差异能影响药物在人体细胞内的累积.他们对人体细胞的培养和普通的抗癌药物的研究结果将在2007年2月5日双月刊杂志《ACS's Molecular Pharmaceutics》发表.
"The demonstrated correlation between hydrogen peroxide exposure and the concomitant increase in drug accumulation represents a substantial finding," the study reports. "The results suggest that patients experiencing oxidative stress (or an increase in hydrogen peroxide levels) may have an increased response to a given dosage of a drug relative to a patient with decreased oxidative stress, or those patients chronically taking antioxidants [such as vitamins C or E] with their medications. This could be a very important factor in our continued efforts to provide more individualized dosing of drugs."
"他们的研究指出了暴露于过氧化氢环境和伴随药物逐渐累积之间的关联性,这也代表了一个有潜力的研究方向,"该研究指出,"这些结果表明在氧化应激压力下(或者过氧化物水平逐渐升高)的人们可能对给定的药物剂量产生不同的反应、病人不断增加的氧化应激或者长期服用抗过氧化物药物(如Vc或者Ve)有关系.这可能是我们今后研制适应特别个体需要的药物剂量一个非常重要的因素.
Hydrogen peroxide's effects could be especially important in about two dozen so-called narrow therapeutic index drugs (such as aminophylline, carbamazepine, lithium , phenytoin, theophylline and warfarin) for which very small changes in dosage level could cause either subtherapeutic or toxic results, they note.
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作者:admin@医学,生命科学 2011-02-19 17:11
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