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【bio-news】序列测定新篇章启动
Next Chapter in Sequencing Launched
By Jennifer Couzin
ScienceNOW Daily News
20 November 2006
The era of sequencing an organism for sequence's sake is coming to an end. Today, the National Human Genome Research Institute (NHGRI) in Bethesda, Maryland, announced it will pour more than $116 million into three sequencing centers, which will use "large-scale" sequencing to focus on unraveling the sources of disease and elucidating the workings of disease-causing organisms. The hefty grants will go to three of the key participants in the Human Genome Project: Eric Lander of the Broad Institute in Cambridge, Massachusetts, Richard Wilson of Washington University in St. Louis, Missouri, and Richard Gibbs of Baylor College of Medicine in Houston, Texas.
The human genome was officially completed in 2003 (ScienceNOW, 14 April 2003), and since then scientists have sequenced everything from the mouse to the chimpanzee to, most recently, the honeybee and sea urchin (ScienceNOW, 25 October). Studies like these have spurred the field of comparative genomics, as scientists seek to better understand relationships between species and how they evolved. Meanwhile, gene-sequencing technology has progressed by leaps and bounds, becoming far cheaper in the process.
The next step, as NHGRI sees it, is to begin devoting resources to projects that will result in more immediate medical benefits. Those include endeavors such as the Cancer Genome Atlas, which NHGRI launched with the National Cancer Institute almost a year ago to identify the gene changes that lead to cancer. The initial results were reported in September (Science, 15 September 2006, p. 1370). So why do more large-scale sequencing? "We have such a long way to go before we understand the inner workings of the human genome" and how it's linked to disease, says Eric Green, NHGRI's scientific director and head of the National Institutes of Health intramural sequencing center. "We're only going to learn that by generating lots more sequencing data."
With that in mind, NHGRI next year plans to award $48 million to the Broad Institute Sequencing Platform, $41 million to Washington University's Genome Sequencing Center, and $27.6 million to the Human Genome Sequencing Center at Baylor. The grants run for 4 years, and how much each center gets after next year will depend on the agency's funding, says Jane Peterson, NHGRI's associate director of extramural research.
"It's an exciting time in sequencing," says Edward Rubin, director of the Department of Energy's Joint Genome Institute, in Walnut Creek, California. "The future landscape has really changed." 本人已认领,若48小时未交译文,请其他战友继续! Next Chapter in Sequencing Launched
序列测定新篇章启动
By Jennifer Couzin
Jennifer Couzin 撰写
ScienceNOW Daily News
每日现代科学报道
20 November 2006
2006年11月20日
The era of sequencing an organism for sequence's sake is coming to an end. Today, the National Human Genome Research Institute (NHGRI) in Bethesda, Maryland, announced it will pour more than $116 million into three sequencing centers, which will use "large-scale" sequencing to focus on unraveling the sources of disease and elucidating the workings of disease-causing organisms. The hefty grants will go to three of the key participants in the Human Genome Project: Eric Lander of the Broad Institute in Cambridge, Massachusetts, Richard Wilson of Washington University in St. Louis, Missouri, and Richard Gibbs of Baylor College of Medicine in Houston, Texas.
因此个别序列缘故而对生物体进行序列测定的时代已经结束。今天，马里兰巴斯达人类基因组研究所(NHGRI)宣布，他们将投入大约116百万美元到三个序列测定中心，这三个中心将使用“大规模”序列测定，以集中解决疾病基因来源和解释疾病导致的器官工作情况。重点资助将给予三个人类基因计划的主要参与者：麻萨诸塞州剑桥大学研究院的Eric Lander，密苏里华盛顿大学的Richard Wilson和得克萨斯州休斯顿大学医学院的Richard Gibbs。
The human genome was officially completed in 2003 (ScienceNOW, 14 April 2003), and since then scientists have sequenced everything from the mouse to the chimpanzee to, most recently, the honeybee and sea urchin (ScienceNOW, 25 October). Studies like these have spurred the field of comparative genomics, as scientists seek to better understand relationships between species and how they evolved. Meanwhile, gene-sequencing technology has progressed by leaps and bounds, becoming far cheaper in the process.
人类基因组计划于2003年完成（2003年4月14日现代科学杂志），自从科学家们将小鼠到猩猩的序列测定出来以后，最近，将测定蜜蜂和海胆的序列（10月25日现代科学杂志）。当科学家寻找对基因的变异进行更好的理解时，这些类似的研究促进了比较基因组学的研究兴起。同时，基因序列分析技术有了跳跃式和更广阔的进步，并且处理过程变的更加便宜。
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作者:admin@医学,生命科学 2011-05-06 05:11
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