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【bio-news】Identical genetics theory questioned－－人类遗
By Patricia Reaney
November 23, 2006 09:34am
ONE person's DNA code can be as much as 10 percent different from another's - a finding that questions the idea that everyone on Earth is 99.9 percent identical genetically.
They said their new version of the human genetic map, or "book of life," fills in many missing pages and chapters to explain how genes are involved in common diseases.
"This important work will help identify genetic causes of many diseases," Britain's Wellcome Trust director Dr Mark Walport said.
Instead of showing single variations in human DNA that make people unique, the map looks at differences in duplications and deletions of large DNA segments known as copy number variants or CNVs, which can help explain why some people are susceptible to illnesses such as AIDS and others are not.
"We're a patchwork of DNA sequences, gains and losses," Boston Medical School's Dr Charles Lee said.
Scientists from more than a dozen centers around the world identified about 3000 genes with variations in the number of copies of specific DNA segments. The changes can affect gene activity, including susceptibility to diseases.
The Human Genome Project mapped the billions of letters that make up the human genetic code.
Scientists later refined the map by looking for single variations called SNPs or single nucleotide polymorphisms.
The CNV map gives researchers a different way to look for genes linked to diseases by identifying gains, losses and alterations in the genome.
"We estimate this to be at least 12 percent of the genome, similar in extent to SNPs. This has never been shown before," Trust Sanger Institute's Dr Matthew Hurles said.
He said that resistance to infection by HIV, the virus that causes AIDS, is determined in part by multiple copies of the gene CCL3L1, which cannot be seen on an SNP map.
http://www.news.com.au/couriermail/story/0,23739,20807460-5003402,00.html 本人已经认领此文. 如在48小时内未能提交译文, 其他战友可自由认领. 本人初访此处,想请教如何查DNA序列
请到核酸版，或利用丁香园的搜索功能，相信会得到满意的答案 既然楼上的师兄
没有翻译
我就接着申请了～～
本人已认领该文编译，48小时（30日）后若未提交译文，请其他战友自由认领 大家看这个文章的时候，可以看一下本系列的这个相关文章http://www.dxy.cn/bbs/post/view?bid=116&id=7581020&sty=3&age=10&tpg=1&ppg=1#7581020 Identical genetics theory questioned
By Patricia Reaney
November 23, 2006 09:34am
同一基因理论遭置疑（不知道翻译的准确不？）
ONE person's DNA code can be as much as 10 percent different from another's - a finding that questions the idea that everyone on Earth is 99.9 percent identical genetically.
一项研究显示，一个人的ＤＮＡ密码子差不多有10％是和别人不同的，这冲击了所有人99.9％基因相同的理论。
They said their new version of the human genetic map, or "book of life," fills in many missing pages and chapters to explain how genes are involved in common diseases.
他们认为新版本的人类遗传图谱或者生命之书填补了如何解释基因与常见疾病关系的许多空白。
"This important work will help identify genetic causes of many diseases," Britain's Wellcome Trust director Dr Mark Walport said.
Britain's Wellcome Trust 的首席医生Mark Walport认为“这项重要的研究将有助于发现许多疾病的遗传学原因”。
Instead of showing single variations in human DNA that make people unique, the map looks at differences in duplications and deletions of large DNA segments known as copy number variants or CNVs, which can help explain why some people are susceptible to illnesses such as AIDS and others are not.
这个基因谱着眼于大的DNA片段的复制和缺失，比如重复数目突变（CNVs），而不是人类DNA的单个变异，来解释每个人为何不同。这将有助于解释为什么有些人易患某种疾病 ，如艾滋病，而别人却不。
"We're a patchwork of DNA sequences, gains and losses," Boston Medical School's Dr Charles Lee said.
“我们是由DNA序列拼凑起来的，获得或者丢失”波士顿医科大学的医生Dr Charles说道。
Scientists from more than a dozen centers around the world identified about 3000 genes with variations in the number of copies of specific DNA segments. The changes can affect gene activity, including susceptibility to diseases.
世界上许多研究中心的科学家发现了约3000种在特定的DNA片段上发生拷贝数目变异的基因。这种变化将影响基因的活性，包括对疾病的易感性。
The Human Genome Project mapped the billions of letters that make up the human genetic code.
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作者:admin@医学,生命科学 2011-05-08 05:11
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