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【medical-news】新方法检查心率不齐
The researchers demonstrated that the receptor which the virus uses to infect heart cells is normally necessary for regular heart beat in mice. Likewise, when the receptor is absent or non-functioning, arrhythmia occurs. They assume that both the virus infection and the autoimmune disease can block the receptor which, in turn, disrupts the heart's normal rhythm.
The heart consists of two ventricles and two atria. In order to beat correctly and to pump blood through the body, specialized heart fibres generate electric signals that control the heart beat. Cardiac arrhythmia occurs when these signals are not correctly generated or forwarded. There, a receptor, which scientists call CAR, plays an important role.
CAR stands for Coxsackievirus-Adenovirus-Receptor. It is embedded in specific cell-cell-contacts (tight junctions) of the specialized heart fibres. CAR was discovered as the critical protein responsible for virus entry during infection with Coxsackie and Adenoviruses. Its role in the adult heart was previously unknown.
To investigate CAR's task in a healthy organism, the MDC-scientists switched off the CAR-gene in adult mice. As a result, the rodents could no longer produce the receptors and developed cardiac arrhythmia. "That is an interesting observation because these special cell-cell-contacts, the tight junctions, have not been connected to arrhythmia so far", Professor Gotthardt says.
A detailed analysis of the animals showed that the transfer of electric signals from the atria to the ventricles does not work properly. "When CAR is missing, the signal can not be passed on and the heart does not beat properly," Dr. Shi says.
Professor Gotthardt now wants to investigate whether CAR is blocked in patients with arrhythmia. "However, it does not always have to be connected to a virus infection," he says. "The body's own antibodies directed against CAR could cause the disease as well."
http://www.mphtimes.com/us/index.php?option=com_content&view=article&id=773:new-mechanism-for-cardiac-arrhythmia-discovered&catid=49:cardiovascular-cardiology&Itemid=66 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 It has long been thought that virus infections can cause cardiac arrhythmia. But why has not been understood. Ulrike Lisewski, Dr. Yu Shi, Michael Radke and Professor Michael Gotthardt of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now discovered the molecular mechanism.
长期以来科学家一直认为病毒感染可引起心律失常，但是为什么至今没有得到理解？德国柏林最高德尔布吕克分子医学中心（MDC）的Ulrike Lisewski，Yu Shi博士，Michael Radke和Michael Gotthardt教授现已发现这个分子机制。
The researchers demonstrated that the receptor which the virus uses to infect heart cells is normally necessary for regular heart beat in mice. Likewise, when the receptor is absent or non-functioning, arrhythmia occurs. They assume that both the virus infection and the autoimmune disease can block the receptor which, in turn, disrupts the heart's normal rhythm.
研究表明在小鼠研究中，该病毒感染心肌细胞所使用的受体是正常心脏跳动所必须的。同样，当受体缺乏或功能障碍时，则会发生心律失常。他们认为病毒感染和自身免疫性疾病均可以阻止受体，这反过来又破坏了心脏的正常节律。
The heart consists of two ventricles and two atria. In order to beat correctly and to pump blood through the body, specialized heart fibres generate electric signals that control the heart beat. Cardiac arrhythmia occurs when these signals are not correctly generated or forwarded. There, a receptor, which scientists call CAR, plays an important role.
心脏由两个心室和两个心房构成。为了准确搏动并将血液泵至全身各部，专职的心脏纤维产生电信号以控制心跳。当这些信号没有正确生成或转交时会发生心律失常。一个被科学家称为CAR的受体发挥着重要作用。
CAR stands for Coxsackievirus-Adenovirus-Receptor. It is embedded in specific cell-cell-contacts (tight junctions) of the specialized heart fibres. CAR was discovered as the critical protein responsible for virus entry during infection with Coxsackie and Adenoviruses. Its role in the adult heart was previously unknown.
CAR是一种柯萨奇病毒-腺病毒-受体。这是植根于特定细胞细胞接触（紧密连接）的专门性纤维。CAR被发现是负责病毒感染柯萨奇病毒和腺病毒进入通道的关键蛋白。它在成人心脏的作用是前所未知的。
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作者:admin@医学,生命科学 2011-03-24 13:59
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