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【medical-news】CPAP增强梗阻性睡眠呼吸暂停/呼吸减
NEW YORK (Reuters Health) Aug 08 - Continuous positive airway pressure (CPAP) therapy improves endothelial-dependent and -independent vasodilatation in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS), according to a report in the July Thorax.
OSAHS is associated with an increased risk of cardiovascular and cerebrovascular disease, the authors point out, but the mechanism of the association is unclear.
Dr. Melanie D. Cross and colleagues from the University of Edinburgh, UK sought to determine whether endothelial function is altered in patients with OSAHS and to determine whether any dysfunction is reversible with CPAP therapy. Twenty-seven participants had more than twenty 4% desaturations per hour ("desaturators"), while 19 subjects had no more than five 3% desaturations per hour ("non-desaturators").
Vasodilating agents, whether endothelium-dependent or -independent, caused a dose-related increase in forearm blood flow in all subjects, the investigators found, but desaturators showed blunted increases in comparison with non-desaturators.
Higher apnea-hypopnea index and desaturation frequency were associated with lower maximum vasodilatation, the report indicates.
Treatment with CPAP did not affect baseline forearm blood flow, the investigators say, but treatment with CPAP for 6 weeks improved forearm blood flow response to all vasodilators.
"Together, these important and novel findings suggest that vascular dysfunction is related to disease severity in OSAHS, and that effective treatment with CPAP can improve vascular function and consequently reduce the associated cardiovascular complications," the researchers conclude.
Thorax 2008;63:578-583. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 【粗译】
红色部分把握不大，其他翻译部分也请各位多指导，谢谢！！！ 【编译】
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作者:admin@医学,生命科学 2011-03-15 17:12
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