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【技术产业】组织工程学与颅面重构
Tissue Engineering For Craniofacial Reconstruction
Article Date: 28 Mar 2007 - 1:00 PDT
Tissue engineering has emerged as a promising alternative for the reconstitution of lost or damaged organs and tissues, circumventing the complications associated with traditional transplants. Tissue engineers attempt to repair or regenerate damaged tissue by using engineered tissue substitutes that can sustain functionality during regeneration and eventually integrate into the host tissue. The traditional tissue-engineering paradigm combines isolated cells with appropriate bioactive agents in a biomaterial scaffold. It is widely recognized that scaffold architecture can profoundly influence the behavior of cells on tissue-engineering constructs.
During the 85th General Session of the International Association for Dental Research, scientists are reporting on High Internal Phase Emulsion (HIPE) polymerization, which affords tremendous control of scaffold morphology. HIPEs can be readily molded into the irregular shapes often required in craniofacial reconstruction and cured in situ to a rigid foam. They have demonstrated that emulsion templating can be used to generate rigid, biodegradable scaffolds with interconnected pores. These scaffolds are of particular interest in craniofacial tissue engineering, due to the rigidity of the resulting foams and the ease of fabrication. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Tissue Engineering For Craniofacial Reconstruction
组织工程和颅面重建
Article Date: 28 Mar 2007 - 1:00 PDT
发表日期：2007年3月28日 1：00 PDT
Tissue engineering has emerged as a promising alternative for the reconstitution of lost or damaged organs and tissues, circumventing the complications associated with traditional transplants.
组织工程学的出现为组织器官缺损的修复重建提供了一个颇具前景的选择，有望防止传统移植带来的并发症。
Tissue engineers attempt to repair or regenerate damaged tissue by using engineered tissue substitutes that can sustain functionality during regeneration and eventually integrate into the host tissue.
组织工程学家试图通过使用在组织修复过程中能够维持组织功能并最终与损伤组织相容的组织工程替代物来修复或再生损伤组织。
The traditional tissue-engineering paradigm combines isolated cells with appropriate bioactive agents in a biomaterial scaffold.
传统的组织工程的模式是使孤立的细胞在生物材料支架中与适当的生物活性因子相结合。
It is widely recognized that scaffold architecture can profoundly influence the behavior of cells on tissue-engineering constructs.
支架结构能够深刻的影响细胞在组织工程构建中的行为，这一观点已获得了广泛的认同。
During the 85th General Session of the International Association for Dental Research, scientists are reporting on High Internal Phase Emulsion (HIPE) polymerization, which affords tremendous control of scaffold morphology.
在第85届国际牙科研究协会大会期间，科学家们对高分散相乳液（HIPE）的聚合作用进行了报道，这一作用可以对支架形态学提供极好的控制。
HIPEs can be readily molded into the irregular shapes often required in craniofacial reconstruction and cured in situ to a rigid foam.
HIPEs 能很容易的根据颅面修复的需求塑造为各种不规则形状并原位愈合为坚硬的泡沫状。
They have demonstrated that emulsion templating can be used to generate rigid, biodegradable scaffolds with interconnected pores.
他们已经证明该乳液模版可用于构建坚硬的、可生物讲解的、具有互联空隙的支架。
These scaffolds are of particular interest in craniofacial tissue engineering, due to the rigidity of the resulting foams and the ease of fabrication.
由于具有稳固的多孔结构以及构建的易操作性，这些支架将对颅面组织工程产生特殊的影响。
整理后：
组织工程和颅面重建
发表日期：2007年3月28日 1：00 PDT
组织工程学的出现为组织器官缺损的修复重建提供了一个颇具前景的选择，有望因此防止传统移植带来的并发症。组织工程学家试图通过使用在组织的修复过程中能够替代其功能并最终与之相容的组织工程替代物来修复或再生损伤组织。传统的组织工程模式是使孤立的细胞在生物材料支架中与适当的生物活性因子相结合。一个获得广泛的认同的观点是支架结构能够深刻的影响细胞在组织工程构建中的行为。
在第85届国际牙科研究协会大会期间，一些科学家对高分散相乳液（HIPE）的聚合作用进行了报道，这一作用可对支架的形态学提供极好的控制。HIPEs 能很容易的根据颅面修复的需求塑造为各种不规则形状并原位愈合为坚硬的泡沫状。他们已经证明该乳液模版可用于构建坚硬的、可生物讲解并具有互连孔隙的支架。由于其稳固的多孔结构以及构建的易操作性，这些支架将对颅面组织工程产生特殊的影响。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-15 17:11
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