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【J Clin Oncol】高风险乳腺癌妇女双侧预防性乳房
Purpose: To prospectively evaluate body image, sexuality, emotional reactions (anxiety, depression), and quality of life in a sample of women having increased risk for breast cancer before and 6 months and 1 year after bilateral prophylactic mastectomy (BPM), and to compare preoperative expectations of the operation with postoperative reactions concerning the impact on six areas of the women's lives.
Patients and Methods: A total of 90 of 98 consecutive women who underwent BPM during October 1997 to December 2005 were included. Data were collected by self-administered questionnaires (eg, Hospital Anxiety and Depression scale, Swedish Short Term-36 Health Survey, Body Image Scale, Sexual Activity Questionnaire) before the operation (n = 81), and 6 (n = 71) and 12 months (n = 65) after BPM.
Results: Anxiety decreased over time (P = .0004). No corresponding difference was found for depression. No differences in health-related quality of life over time were found, with one exception. A substantial proportion of the women reported problems with body image 1 year after BPM (eg, self consciousness, 48%; feeling less sexually attractive, 48%; and dissatisfaction with the scars, 44%). Sexual pleasure was rated lower 1-year post-BPM as compared with before operation (P = .005), but no differences over time in habit, discomfort, or activity were found.
Conclusion: No negative effects on anxiety, depression, and quality of life were found. Anxiety and social activities improved. Negative impact on sexuality and body image was reported.
http://jco.ascopubs.org/cgi/content/abstract/26/24/3943 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Psychological Reactions, Quality of Life, and Body Image After Bilateral Prophylactic Mastectomy in Women At High Risk for Breast Cancer: A Prospective 1-Year Follow-Up Study
高风险乳腺癌妇女双侧预防性乳房切除术后的心理反应，生活质量和身体形象：随访1年的前瞻性研究
Purpose: To prospectively evaluate body image, sexuality, emotional reactions (anxiety, depression), and quality of life in a sample of women having increased risk for breast cancer before and 6 months and 1 year after bilateral prophylactic mastectomy (BPM), and to compare preoperative expectations of the operation with postoperative reactions concerning the impact on six areas of the women's lives.
目的：预测评估乳腺癌风险升高的妇女在双侧预防性乳房切除术（BPM）前，术后6个月和1年的身体形象，性欲，情感反应（焦虑，抑郁）和生活质量，并在妇女生活的六个方面比较术前预期和术后反应。
Patients and Methods: A total of 90 of 98 consecutive women who underwent BPM during October 1997 to December 2005 were included. Data were collected by self-administered questionnaires (eg, Hospital Anxiety and Depression scale, Swedish Short Term-36 Health Survey, Body Image Scale, Sexual Activity Questionnaire) before the operation (n = 81), and 6 (n = 71) and 12 months (n = 65) after BPM.
病人和方法：从1997年10月到2005年12月接连经历BPM的总数为98个妇女中的90位。通过BPM术前（n=81），术后6个月（n=71）和术后12个月（n=65）自行填写调查表收集数据（如医院焦虑与抑郁量表，瑞典短期-36健康调查，身体形象量表，性行为调查表）
Results: Anxiety decreased over time (P = .0004). No corresponding difference was found for depression. No differences in health-related quality of life over time were found, with one exception. A substantial proportion of the women reported problems with body image 1 year after BPM (eg, self consciousness, 48%; feeling less sexually attractive, 48%; and dissatisfaction with the scars, 44%). Sexual pleasure was rated lower 1-year post-BPM as compared with before operation (P = .005), but no differences over time in habit, discomfort, or activity were found.
结果：焦虑症状随时间推延而减轻（P= .0004）。抑郁症状没有发现相应的差别。随时间推延，除一例外，没有发现与健康相关的生活质量变化。BPM术后1年有相当大比例的妇女报告身体形象的问题（如自我意识，48%；感觉性吸引力减低，48%；和对疤痕不满意，44%）。与术前相比，性生活乐趣评估在BPM术后1年降低（P= .005），但没有发现习惯，舒适度，行为的改变。
Conclusion: No negative effects on anxiety, depression, and quality of life were found. Anxiety and social activities improved. Negative impact on sexuality and body image was reported.
结论：没有发现对焦虑，抑郁，生活质量的负面影响。焦虑和社会行为有所改进。发现了对性生活和身体形象的负面影响。
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作者:admin@医学,生命科学 2011-02-08 05:14
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