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【bio-news】自身免疫疾病基因与子痫前症有关联
Autoimmune Genes Linked To Preeclampsia
Researchers at North Carolina State University have discovered that the placentas of women who suffer preeclampsia during pregnancy have an overabundance of a gene associated with the regulation of the body's immune system. Their discovery may lead to improved screening and prenatal care for these patients and their babies.
Preeclampsia occurs in up to 10 percent of all pregnancies, and is responsible for about 15 percent of pre-term births. The disorder is usually marked by a rapid rise in blood pressure that can lead to stroke, seizures or organ failures in the mother. Researchers have recently begun looking at preeclampsia as an autoimmune disorder, in which the mother's body treats the placenta like an invader, but they weren't sure of the genetic mechanisms involved.
Dr. Jorge Piedrahita, professor of genomics, along with colleagues from NC State and the Duke University School of Medicine, examined the genetic makeup of placentas from women with preeclampsia and compared the results to those from normal pregnancies. Their results are published in the February issue of the journal Placenta.
"When we looked at the preeclampsic placentas, we found that several genes associated with a particular autoimmune pathway were 'upregulated' basically, that there were more of them in placentas of preeclampsic women than in normal placentas," Piedrahita says. "More specifically, we found the upregulation of a particular enzyme involved in sialic acid modification called SIAE. Sialic acid coats every cell in our body, making it possible for our immune system to distinguish 'self' from 'not-self.' If this process is disrupted, the body can end up attacking itself."
The researchers were excited by this finding because SIAE has recently been linked to autoimmune diseases like rheumatoid arthritis and type I diabetes.
"Prior to this research, we knew that there was an autoimmune cascade effect with preeclampsia, but we didn't know where it originated," Piedrahita adds. "Now we know that disregulation of SIAE helps start the cascade. We've been able to fill in the blanks, and hopefully pregnant women and their babies will benefit as a result."
The research was funded by a grant from the National Institutes of Health. The Department of Molecular Biomedical Sciences and the Center for Comparative Medicine and Translational Research are part of NC State's College of Veterinary Medicine.
Source: North Carolina State University
http://www.medicalnewstoday.com/articles/216455.php 认领48h。 自身免疫疾病基因与子痫前症有关联
Autoimmune Genes Linked To Preeclampsia
Researchers at North Carolina State University have discovered that the placentas of women who suffer preeclampsia during pregnancy have an overabundance of a gene associated with the regulation of the body's immune system. Their discovery may lead to improved screening and prenatal care for these patients and their babies.
北卡罗来纳州大学的研究人员发现有子癫前症的怀孕妇女的胎盘有大量的与身体免疫系统调节相关的基因子。他们的发现有助于改善这些父母和宝宝的产品筛查和保健。
Preeclampsia occurs in up to 10 percent of all pregnancies, and is responsible for about 15 percent of pre-term births. The disorder is usually marked by a rapid rise in blood pressure that can lead to stroke, seizures or organ failures in the mother. Researchers have recently begun looking at preeclampsia as an autoimmune disorder, in which the mother's body treats the placenta like an invader, but they weren't sure of the genetic mechanisms involved.
子癫前症的发生率在孕妇中高达10%，而且早产儿中15%与之有关。该病征以血压急剧上升为标志，导致中风、癫痫或母体的器官衰竭。研究人员最近开始认为子癫前症是一中自主免疫紊乱疾病，导致母体视胎盘为入侵者，但是他们不确定是否与基因机制有关。
Dr. Jorge Piedrahita, professor of genomics, along with colleagues from NC State and the Duke University School of Medicine, examined the genetic makeup of placentas from women with preeclampsia and compared the results to those from normal pregnancies. Their results are published in the February issue of the journal Placenta.
基因学教授Jorge Piedrahita博士和他在北卡罗来纳州大学和杜克医学院的同事们，研究有子癫前症的妇女的胎盘基因组成并与正常的怀孕妇女做对比。他们的研究结果发表在《胎盘》二月份期刊上。
"When we looked at the preeclampsic placentas, we found that several genes associated with a particular autoimmune pathway were 'upregulated' basically, that there were more of them in placentas of preeclampsic women than in normal placentas," Piedrahita says. "More specifically, we found the upregulation of a particular enzyme involved in sialic acid modification called SIAE. Sialic acid coats every cell in our body, making it possible for our immune system to distinguish 'self' from 'not-self.' If this process is disrupted, the body can end up attacking itself."
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作者:admin@医学,生命科学 2011-02-16 11:54
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