主页 > 生命科学 >
【文摘发布】尿液NAG酶活性和肾脏损伤分子—1水
Urinary N-Acetyl--(D)-Glucosaminidase Activity and Kidney Injury Molecule-1 Level Are Associated with Adverse Outcomes in Acute Renal Failure
Orfeas Liangos*,, Mary C. Perianayagam*, Vishal S. Vaidya, Won K. Han, Ron Wald, Hocine Tighiouart||, Robert W. MacKinnon*, Lijun Li, Vaidyanathapuram S. Balakrishnan, Brian J.G. Pereira, Joseph V. Bonventre and Bertrand L. Jaber*,
* Division of Nephrology, Caritas St. Elizabeth’s Medical Center, Division of Nephrology and || Biostatistics Research Center, Tufts-New England Medical Center, and Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts; and Division of Nephrology, St. Michael’s Hospital, Toronto, Ontario, Canada
The role of urinary biomarkers of kidney injury in the prediction of adverse clinical outcomes in acute renal failure (ARF) has not been well described. The relationship between urinary N-acetyl--(D)-glucosaminidase activity (NAG) and kidney injury molecule-1 (KIM-1) level and adverse clinical outcomes was evaluated prospectively in a cohort of 201 hospitalized patients with ARF. NAG was measured by spectrophotometry, and KIM-1 was measured by a microsphere-based Luminex technology. Mean Acute Physiology, Age, Chronic Health Evaluation II (APACHE II) score was 16, 43% had sepsis, 39% required dialysis, and hospital mortality was 24%. Urinary NAG and KIM-1 increased in tandem with APACHE II and Multiple Organ Failure scores. Compared with patients in the lowest quartile of NAG, the second, third, and fourth quartile groups had 3.0-fold (95% confidence interval [CI] 1.3 to 7.2), 3.7-fold (95% CI 1.6 to 8.8), and 9.1-fold (95% CI 3.7 to 22.7) higher odds, respectively, for dialysis requirement or hospital death (P < 0.001). This association persisted after adjustment for APACHE II, Multiple Organ Failure score, or the combined covariates cirrhosis, sepsis, oliguria, and mechanical ventilation. Compared with patients in the lowest quartile of KIM-1, the second, third, and fourth quartile groups had 1.4-fold (95% CI 0.6 to 3.0), 1.4-fold (95% CI 0.6 to 3.0), and 3.2-fold (95% CI 1.4 to 7.4) higher odds, respectively, for dialysis requirement or hospital death (P = 0.034). NAG or KIM-1 in combination with the covariates cirrhosis, sepsis, oliguria, and mechanical ventilation yielded an area under the receiver operator characteristic curve of 0.78 (95% CI 0.71 to 0.84) in predicting the composite outcome. Urinary markers of kidney injury such as NAG and KIM-1 can predict adverse clinical outcomes in patients with ARF. 本人认领此文。如在48小时内未能提交译文，其他战友可自由认领。 初译：
J Am Soc Nephrol 18: 904-912, 2007
Urinary N-Acetyl--(D)-Glucosaminidase Activity and Kidney Injury Molecule-1 Level Are Associated with Adverse Outcomes in Acute Renal Failure尿液NAG酶活性和肾脏损伤分子—1水平与急性肾衰不良预后有关 个人观点，仅供参考：
Urinary N-Acetyl--(D)-Glucosaminidase
尿液NAG酶
尿Ｎ－乙酰－β－Ｄ氨基葡萄糖苷酶（NAG） 衷心感谢谍影重重的翻译和假行家的修改。如果要精益求精地话，还有下列文字可以商讨。
The role of urinary biomarkers of kidney injury in the prediction of adverse clinical outcomes in acute renal failure (ARF) has not been well described.
尿液肾脏损伤生物标记物在预测急性肾衰不良临床后果中的作用还没有被详尽地描述过。[标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-15 17:11
医学,生命科学网