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【J Clin Oncol】舒尼替尼作为治疗转移性肾细胞癌
Purpose: To assess the cost effectiveness and cost utility of sunitinib malate as a first-line treatment in metastatic renal cell carcinoma (mRCC) compared with interferon-alfa (IFN-) and interleukin-2 (IL-2) from a US societal perspective.
Methods: A Markov model was developed to simulate disease progression and to determine progression-free survival, total life-years (LYs), and quality-adjusted life-years (QALYs) gained. Model parameters were derived from the pivotal trial of sunitinib, published literature, government sources, and clinical experts’ opinions. The model included trial-based adverse events (AEs). Costs of drug treatment, routine follow-up, AEs, disease progression, and best supportive care (BSC) of terminally ill patients were included. Results were tested using probabilistic and deterministic sensitivity analyses.
Results: Treatment with sunitinib is associated with a gain in progression-free years of 0.41 and 0.35 over IFN- and IL-2. The estimated gains over IFN- were 0.11 LYs and 0.14 QALYs, and over IL-2 were 0.24 LYs and 0.20 QALYs. Both IFN- and sunitinib treatments dominate IL-2 treatment; the incremental cost-effectiveness ratio of sunitinib versus IFN- was $18,611 per progression-free year gained and $67,215 per LY gained, and the cost-utility ratio is $52,593 per QALY gained (at a 5% discount rate). Sensitivity analyses found the results to be most sensitive to utility values during treatment, the cost of sunitinib, and the cost of BSC. Model results were robust to changes in other model variables.
Conclusion: These results suggest that sunitinib is a cost-effective alternative to IFN- as a first-line treatment for mRCC.
http://jco.ascopubs.org/cgi/content/abstract/26/24/3995 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-01-26 17:14
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