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【medical-news】不再需要注射胰岛素，移植细胞即
不再需要注射胰岛素，移植细胞即可治疗糖尿病
The first international test of a method using transplanted pancreas cells in diabetes patients has shown some success.
首次全球实验发现，对糖尿病患者应用移植胰腺细胞见成效，
The technique which was first revealed in 2000, has become known as the Edmonton protocol, and uses processed pancreas islets derived from dead donors, to produce the insulin needed to process blood sugar in severe Type 1 diabetes patients.
对糖尿病患者移植胰腺细胞的技术被称为Edmonton 草案，发明于2000年。该技术利用经过加工的已逝捐赠者的胰岛，令其在重症I型糖尿病患者体内产生胰岛素，调节患者血糖于正常值。
The trial, led by University of Alberta researcher Dr. James Shapiro, eliminated the need for insulin in some diabetes patients, but for many the benefit was only a short term one.
这次实验的主持者为Alberta 大学的研究员，Dr， James Shapiro. 该实验表明，此技术可使少部分患者不再需要注射胰岛素，大部分患者的仅得到短时间的受益。
Dr. Shapiro says the processed cells were tested on 36 severe case patients in North America and Europe in order to gauge how well the transplanted islets would function in regulating blood sugars.
Dr， James Shapiro 对南美和欧洲的36位重症糖尿病患者应用加工过的胰岛，来估计移植的胰岛调节患者血糖的作用，
While 44 per cent of the transplant recipients no longer needed insulin injections a year after their final treatment, 28 per cent had only partial islet function and the benefit did not persist indefinitely in most cases.
尽管44%的移植受体在接受最终治疗后一年内不再需要注射胰岛素，28%的患者的胰岛功能仅得到了部分的发挥。对大多数患者来说，其益处也不再是模糊不可测的。
Dr. Shapiro says the transplanted cells appeared to stop working because not enough survived the initial transplant.
Dr， James Shapiro 称移植细胞停止工作是由于首次移植中，并没有足够的细胞存活下来。
However, individuals with functioning islets had improved control of their diabetes, even though they still needed to take insulin shots.
然而，拥有又功能胰岛细胞的个体能够提高对糖尿病的控制能力，尽管他们仍然需要注射胰岛素。
Type 1 diabetes affects up to 2 million Americans, it is usually diagnosed in young people and can increase the risk for many major illnesses such as heart attacks, stroke and kidney disease.
I型糖尿病影响到了2，000，000的美国人。年轻人经常被检查出来有该疾病。该病可以提高例如心脏病发作、中风以及肾脏疾病等主要疾病的发病机率。
The researchers say more work is needed before the technique approaches the success rate of an entire pancreas transplant, where the success rate is 50 to 70 percent even after five years.
研究者声称，在移植的成功率达到100%之前还要做许多工作。在5年后，该成功率能达到50%-70%。
Both techniques are risky because patients must then take drugs that suppress the immune system which can have serious side effects.
所有的技术都有危险，因为患者必须在移植之后服用一直免疫系统的药物，该种药物带有严重的副作用。
Shapiro says this is the first time a multicentre, international trial has been done in islet research and shows that islet transplantation can be very successful in protecting against hypoglycemic unawareness.
Shapiro称这是首次对于胰岛研究的多中心、国际性的研究，表明胰岛移植能够非常成功的防治不伴警告症状低血糖。 胰岛细胞移植――糖尿病患者的福音
I型糖尿病影响到了大约2，000，000的美国人的生活，很多人往往在很年轻时即已患有此疾病，进而会提高心脏病、中风以及肾脏疾病的发病率。目前首次国际性合作研究发现移植胰岛细胞对I型糖尿病治疗已初见成效。
对糖尿病患者移植胰腺细胞的技术被称为Edmonton规范，提出于2000年。该技术将经过加工的已逝捐赠者的胰岛植入患者体内，令其在患者体内存活并产生胰岛素，进而调节患者血糖至正常水平。
这次实验的主持者为Alberta 大学的研究员James Shapiro博士。研究者对南美和欧洲的36位重症糖尿病患者进行了胰岛移植，其中有44%的移植受体在接受移植后的一年内不再需要注射胰岛素，28%的患者移植的胰岛功能发挥了部分作用，对大多数患者来说，在一定程度上还是颇为受益。
James Shapiro博士认为之所移植胰岛只有部分作用得以发挥，其它仍有赖于注射胰岛素的原因是由于首次移植的细胞数目较少，以至于没有足够的细胞存活下来所致。即便如此，进行胰岛细胞移植还是有助于对糖尿病的控制。
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作者:admin@医学,生命科学 2011-01-09 05:14
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