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【medical-news】新研究：氟达拉滨可选择性杀死巨
In the July 1st issue of the Journal of Infectious Diseases, Dr. Mauro Magnani and colleagues at the University of Urbino "Carlo Bo" note that M. avium infects mononuclear phagocytes which become reservoirs for the pathogen, a particular problem in patients with AIDS.
Such infection activates the STAT-1 (signal transducer and activator of transcription type 1) pathway. The researchers investigated the utility of the anti-leukemic drug fludarabine, which is active against cells that express STAT-1, in treating macrophages infected with M. avium strains that had been obtained from AIDS patients.
Fludarabine was cytotoxic to infected macrophages, but uninfected macrophages remained viable in the presence of the agent.
Thus, say the investigators, "this work opens the way to experimental therapeutic approaches aimed to selectively eliminate persistently infected cells and mycobacteria that, once released from infected macrophages, become exposed and vulnerable to drug treatment."
"We are convinced," Dr. Magnani told Reuters Health, "that the identification of a new molecular target will now open the possibility for the development of new treatments that could facilitate eradication of this pathogen. Several treatments are available, but eradication is still a major problem."
Furthermore, Dr. Magnani added, "We have preliminary information suggesting that the same cellular pathway is responsible for the survival of different intracellular pathogens in addition to M. avium."
J Infect Dis 2008;198:95-100. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 NEW YORK (Reuters Health) Jul 25 - Mycobacterium avium-infected macrophages are selectively killed by fludarabine, Italian researchers report. They suggest that antibacterial agents could then be used to eliminate bacteria released from the killed cells.
NEW YORK (Reuters Health) 7月25日－意大利研究者报道，fludarabine可以选择性的杀死鸟型分枝杆菌感染的巨噬细胞。建议然后用抗菌剂消灭从被杀死的细胞里释放的细菌。
In the July 1st issue of the Journal of Infectious Diseases, Dr. Mauro Magnani and colleagues at the University of Urbino "Carlo Bo" note that M. avium infects mononuclear phagocytes which become reservoirs for the pathogen, a particular problem in patients with AIDS.
University of Urbino "Carlo Bo"的Dr. Mauro Magnani和同事在7月1日传染病学杂志的一篇文章中提到，鸟型分枝杆菌感染单核巨噬细胞后，单核巨噬细胞就成为病原体的储存地，特别是在AIDS病人。
Such infection activates the STAT-1 (signal transducer and activator of transcription type 1) pathway. The researchers investigated the utility of the anti-leukemic drug fludarabine, which is active against cells that express STAT-1, in treating macrophages infected with M. avium strains that had been obtained from AIDS patients.
这种感染可以激活1型信号转导子和转录激活子（STAT-1）途径。研究者对抗白血病药物fludarabine的作用进行了调查，这个药对表达STAT-1的细胞具有活性，可以治疗被来自于AIDS病人鸟型分枝杆菌感染的巨噬细胞。
Fludarabine was cytotoxic to infected macrophages, but uninfected macrophages remained viable in the presence of the agent.
对于被感染的巨噬细胞，Fludarabine具有细胞毒性，但是未被感染的巨噬细胞在使用Fludarabine时可以保持活性。
Thus, say the investigators, "this work opens the way to experimental therapeutic approaches aimed to selectively eliminate persistently infected cells and mycobacteria that, once released from infected macrophages, become exposed and vulnerable to drug treatment."
调查者说，这个工作开创了一条新的实验性治疗方法，这个方法是为了选择性的根除顽固感染细胞和分枝杆菌的。
"We are convinced," Dr. Magnani told Reuters Health, "that the identification of a new molecular target will now open the possibility for the development of new treatments that could facilitate eradication of this pathogen. Several treatments are available, but eradication is still a major problem."
Dr. Magnani告诉Reuters Health：“我们确信得到确认的一个新的靶分子，将为能够彻底根除这个病原体而研制出新的治疗方法提供了可能。”目前有几种治疗方法，但是要根除还是一个主要问题。
Furthermore, Dr. Magnani added, "We have preliminary information suggesting that the same cellular pathway is responsible for the survival of different intracellular pathogens in addition to M. avium."
此外，Dr. Magnani补充：“我们有初步资料提示，除鸟型分枝杆菌之外，相同的细胞通路使得其他不同细胞间的病原体得以生存。
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作者:admin@医学,生命科学 2011-08-31 05:19
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