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【medical-news】放射治疗儿童期头癣会增加甲状腺
NEW YORK (Reuters Health) Jan 29 - Childhood exposure to ionizing radiation to treat tinea capitis increases the long-term risk of thyroid cancer, according to findings published in the December issue of the Journal of Clinical Endocrinology and Metabolism.
"The thyroid gland is known to be sensitive to the carcinogenic effect of ionizing radiation, especially in children," Dr. Siegal Sadetzki, of Chaim Sheba Medical Center, Tel Hashomer, Israel, and colleagues write.
The researchers assessed the effect of low doses of ionizing radiation on the risk of developing thyroid cancer up to 54 years after exposure in childhood. The study population included 10,834 subjects irradiated against tinea capitis in the 1950s, an equal number of matched nonirradiated subjects taken from the general population, and 5392 nonirradiated siblings. National registries, updated to December 2002, were used to obtain cancer statistics and vital status data.
The subjects were followed for a median of 46 years. The mean age at irradiation was 7.1 years and the mean age at the end of follow-up was 52.1 years. A total of 159 cases of thyroid cancer were diagnosed during the study period (103 in irradiated individuals and 56 in nonirradiated subjects).
The investigators found that the total excess relative risk per gray (ERR/Gy) for developing thyroid cancer was 20.2 per 10,000 person-years. The risk was inversely associated with age at exposure.
"Significantly elevated ERR/Gy was first noticed for latent periods of 10 to 19 years after exposure, reaching about 29 in the 20 to 30 years after exposure," Dr. Sadetzki's team reports. "A dramatic decrease in the ERR was observed 40 years after exposure," they note. "No difference in the ERR was found relative to the number of irradiations."
The investigators say the results are in line, generally, with patterns of risk modification seen in other studies of radiation-induced thyroid cancer. "The carcinogenic effects of low-level radiation," they conclude, "must be considered in the planning of safety measures against public health hazards."
J Clin Endocrinol Metab 2006;91:4798-4804.
http://www.medscape.com/viewarticle/551418 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 放射治疗儿童期头癣会增加甲状腺癌风险
Radiation for Tinea Capitis in Childhood Linked to Risk of Thyroid Cancer
NEW YORK (Reuters Health) Jan 29 - Childhood exposure to ionizing radiation to treat tinea capitis increases the long-term risk of thyroid cancer, according to findings published in the December issue of the Journal of Clinical Endocrinology and Metabolism.
纽约时报(路透社健康消息)1月29日-根据出版在12月份《临床内分泌学和代谢》杂志上的结果，放射治疗儿童期头癣可能会增加甲状腺癌的长期风险。
"The thyroid gland is known to be sensitive to the carcinogenic effect of ionizing radiation, especially in children," Dr. Siegal Sadetzki, of Chaim Sheba Medical Center, Tel Hashomer, Israel, and colleagues write.
以色列 Tel Hashomer的Chaim Sheba医学中心的Siegal Sadetzki医生和他的同时说到，“我们知道甲状腺对电离放射线的至癌作用非常明显，尤其在儿童中。”
The researchers assessed the effect of low doses of ionizing radiation on the risk of developing thyroid cancer up to 54 years after exposure in childhood. The study population included 10,834 subjects irradiated against tinea capitis in the 1950s, an equal number of matched nonirradiated subjects taken from the general population, and 5392 nonirradiated siblings. National registries, updated to December 2002, were used to obtain cancer statistics and vital status data.
研究者在经过54年后评估了经过低计量的电离放射线导致甲状腺癌的风险，这些人在儿童时期经过放射线的治疗。这项研究人群包括20世纪50年代10834名受辐射的受试者对头癣的对抗作用，相同数量的从普通人群中匹配的没有经过辐射的人还有5392名没有受过辐射的亲属。通过使用一直持续到2002年12月的全国性的登记来获取癌症数据和必要的统计数据。
The subjects were followed for a median of 46 years. The mean age at irradiation was 7.1 years and the mean age at the end of follow-up was 52.1 years. A total of 159 cases of thyroid cancer were diagnosed during the study period (103 in irradiated individuals and 56 in nonirradiated subjects).
这项研究跟踪了大概46年。在受到辐射的平均年龄是7.1岁并且结束跟踪调查的平均年龄是52.1岁。在这项研究期间共诊断出159例甲状腺癌（其中103例来自受辐射人群，56例来自非辐射受试者）。
The investigators found that the total excess relative risk per gray (ERR/Gy) for developing thyroid cancer was 20.2 per 10,000 person-years. The risk was inversely associated with age at exposure.
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作者:admin@医学,生命科学 2011-08-22 06:36
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