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【drug-news】Infliximab抑制哮喘恶化
U.K. trial found the drug reduced disease symptoms in mild cases
HealthDay
By Robert Preidt
Monday, October 2, 2006
MONDAY, Oct. 2 (HealthDay News) -- The drug infliximab significantly reduced disease exacerbations in people with moderate asthma, new U.K. research finds.
The eight-week study included 14 patients who received infliximab -- an anti-inflammatory monoclonal antibody -- and 18 patients who received a placebo. During the trial, all the patients continued to use inhaled corticosteroids for their asthma.
Patients who received infliximab experienced significantly fewer asthma exacerbations than those who took the placebo, the study found. There were no adverse side effects associated with infliximab treatment.
Infliximab binds and neutralizes tumor necrosis factor-alpha (TNF-alpha), an intracellular messenger protein (cytokine) associated with inflammation. Both structured and inflammatory cells in asthmatics can release TNF-alpha, the researchers noted.
"Given that infliximab therapy was well-tolerated and appeared to reduce the incidence of asthma exacerbations, anti TNF-alpha therapy merits further study in larger clinical trials in patients with severe asthma," researcher Dr. Trevor T. Hansel of the National Heart and Lung Institute at Royal Brompton Hospital in London, said in a prepared statement.
The study was published in the October issue of the American Journal of Respiratory and Critical Care Medicine. 认领了
Infliximab有助于抑制哮喘恶化
英国一项试验发现该药能减少轻症患者的疾病症状
2006年10月2日 星期一
10月2日 星期一：英国一项新的研究发现：药物infliximab能显著减少中度哮喘患者的疾病恶化。
这研究为期8周，14个患者接受infliximab（抗炎单克隆抗体）治疗，18个患者接受安慰剂治疗。试验中，所有的患者均继续使用吸入型皮质激素治疗哮喘。
研究发现，接受infliximab治疗的患者与接受安慰剂治疗的患者相比，哮喘恶化的次数显著减少。没有发现与Infliximab治疗有关的不良副作用。
Infliximab可以结合并屏蔽肿瘤坏死因子α(TNF-alpha),一种与炎症有关的细胞内信使蛋白（细胞因子）。研究人员强调，哮喘时组织细胞和炎症细胞都能释放TNF-alpha。
位于伦敦的皇家布朗普敦医院国家心肺研究所的研究者Trevor T. Hansel博士在一份准备好的声明中说，“如果infliximab治疗耐受性好，能够减少哮喘恶化的发生，那么抗TNF-alpha药物就应该在患有严重哮喘的患者中进行更大规模的临床试验。”
该研究发表在美国呼吸道与危重症监护医学杂志10月刊。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-07 05:12
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