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【Gastroenterology】高体重指数增加结直肠腺瘤发生
Researchers at the University of Tokyo and Kameda General Hospital in Japan examined the effect of body weight on the incidence of colorectal adenoma in 7,963 Japanese patients who underwent colonoscopy between 1991 and 2003. Patients who had a family history of colorectal cancer, colorectal polyps, inflammatory bowel disease, colorectal surgery or who took NSAIDS were excluded from the study.
In this cross-sectional study, patients were classified into four groups according to their body mass index (BMI). Researchers found 20.7 percent of patients had at least one colorectal adenoma. Importantly, as the BMI increased, so did the prevalence of colorectal adenomas.
In a separate cohort analysis, 2,568 patients from the initial study underwent a second colonoscopy after one year to compare the effect of body weight changes on the development of new colorectal adenomas. The incidence rates of colorectal adenoma were 9.3 percent in patients who lost 5 percent or more in body weight; 16.2 percent in patients who gained 5 percent or more in body weight; and 17.1 percent in patients who neither gained nor lost weight.
Weight loss was associated with lowered incidence of adenoma, independent of gender, age, initial colonoscopic findings, and initial BMI. Based on their findings, the authors suggest that controlling body weight may decrease the risk of developing colorectal adenomas.
According to ACG President Amy E. Foxx-Orenstein, D.O., FACG, "The magnitude of the obesity epidemic adds a staggering burden to our current health care system. These studies point to the serious potential risks of GI disease for individuals who are overweight or obese." 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 High Body Mass Index Increases Risk of Colorectal Adenomas
高体重指数增加了结直肠腺癌的风险。
Researchers at the University of Tokyo and Kameda General Hospital in Japan examined the effect of body weight on the incidence of colorectal adenoma in 7,963 Japanese patients who underwent colonoscopy between 1991 and 2003. Patients who had a family history of colorectal cancer, colorectal polyps, inflammatory bowel disease, colorectal surgery or who took NSAIDS were excluded from the study.
来自日本东京大学和Kameda总医院的研究者对7963名日本患者进行了体重在结直肠腺癌发病率上效应的调查，这些患者于1991年到2003年间进行了结肠镜检。具有家族结直肠肿瘤、结直肠息肉病、炎性肠病、结直肠手术或使用NSAIDS药物的患者排除在该研究之外。
In this cross-sectional study, patients were classified into four groups according to their body mass index (BMI). Researchers found 20.7 percent of patients had at least one colorectal adenoma. Importantly, as the BMI increased, so did the prevalence of colorectal adenomas.
在这一横断面研究中，患者们根据体重指数BMI分成4组。研究者发现20.7％的患者至少有一种结直肠癌。重要的是，随着BMI指数的增长，结直肠腺癌的患病率增高。
In a separate cohort analysis, 2,568 patients from the initial study underwent a second colonoscopy after one year to compare the effect of body weight changes on the development of new colorectal adenomas. The incidence rates of colorectal adenoma were 9.3 percent in patients who lost 5 percent or more in body weight; 16.2 percent in patients who gained 5 percent or more in body weight; and 17.1 percent in patients who neither gained nor lost weight.
在单独队列研究中，进入初始研究中的2568名患者在一年后进行了第二次结肠内镜检查，以比较体重变化在新发结直肠腺癌发病率上的作用。结直肠腺癌发病率在体重减轻5%的患者中为9.3％；在体重增加5％或更多患者中为16.2％；在体重无明显变化患者中为17.1%.
Weight loss was associated with lowered incidence of adenoma, independent of gender, age, initial colonoscopic findings, and initial BMI. Based on their findings, the authors suggest that controlling body weight may decrease the risk of developing colorectal adenomas.
体重减轻和腺癌发病率降低、性别、年龄、初始结直肠镜检和初始BMI相关。基于他们的发现，作者表示控制体重可能降低结直肠腺癌发病率。
According to ACG President Amy E. Foxx-Orenstein, D.O., FACG, "The magnitude of the obesity epidemic adds a staggering burden to our current health care system. These studies point to the serious potential risks of GI disease for individuals who are overweight or obese."
美国胃肠病学会主席Amy E. Foxx-Orenstein认为“肥胖的普遍流行对我们现有的医疗体系是一个惊人的负担。这次研究指出对于超重或肥胖的个人来说，胃肠疾病的潜在风险很严重。”
高体重指数增加了结直肠腺癌的风险。
来自日本东京大学和Kameda总医院的研究者对7963名日本患者进行了体重在结直肠腺癌发病率上效应的调查，这些患者于1991年到2003年间进行了结肠镜检。具有家族结直肠肿瘤、结直肠息肉病、炎性肠病、结直肠手术或使用NSAIDS药物的患者排除在该研究之外。
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作者:admin@医学,生命科学 2011-08-05 06:23
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