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【科普】香烟、幽门螺旋杆菌协同增加胃癌患病
香烟、幽门螺旋杆菌协同增加胃癌患病风险
NEW YORK (Reuters Health) Dec 19 - The combination of cigarette smoking and Helicobacter pylori infection, both well-established risk factors for gastric cancer, creates what Japanese researchers say is "a synergistic association" resulting in an 11-fold increase in the risk of gastric cancer.
The researchers' study, headed by Dr. Yutaka Kiyohara of Kyushu University in Fukuoka City, is reported in the Dec. 15 issue of the American Journal of Epidemiology.
The report is the latest from a long-term population-based study in Hisayama, in a populous region on the Japanese island of Kyushu. According to the 1985 census, the age and occupational distributions in Hisayama were almost identical to those in Japan as a whole.
In 1988, 2,752 Hisayama residents aged 40 years or over (more than 80% of the population in that age group) with no history of gastric cancer were screened for the present study. Because the rate of smoking was low among the women, only men, a total of 1,071, were enrolled.
This group was followed for 14 years, until November 2002. The frequency of cigarette smoking was 42.7% and that of H. pylori infection was 76.9%. Participants received health check-ups every 1 to 2 years, and those who moved away were followed by mail or telephone. Comprehensive efforts to identify all cases of gastric cancer in the study cohort included autopsies of 77% of those who died during the study period.
Gastric cancer was diagnosed in 68 participants, including 1 case diagnosed at autopsy. The interval from baseline to time of cancer diagnosis ranged from 0.5 to 13.7 years.
As expected, both cigarette smoking and H. pylori infection were significant risk factors for gastric cancer after adjustment for confounding factors. The researchers estimated the population attributable fraction (PAF) of gastric cancer for cigarette smoking as 28.4% and that for H. pylori infection as 56.2%.
On multivariate analysis, compared with the risk of gastric cancer in non-smokers without H. pylori, hazard ratios for gastric cancer were 5.82 for smokers without H. pylori, 6.93 for non-smokers with H. pylori, and 11.41 for smokers with H. pylori.
Am J Epidemiol 2008;168:1409-1415. 本人已认领该文翻译，48小时后若未提交译文，请其他战友自由认领 . Cigarettes, H. Pylori Together Greatly Multiply Risk of Gastric Cancer
香烟、幽门螺旋杆菌协同增加胃癌患病风险
NEW YORK (Reuters Health) Dec 19 - The combination of cigarette smoking and Helicobacter pylori infection, both well-established risk factors for gastric cancer, creates what Japanese researchers say is "a synergistic association" resulting in an 11-fold increase in the risk of gastric cancer.
纽约（路透社健康版）12月19日报道——日本研究者们研究发现，吸烟和幽门螺旋杆菌感染，这2种众所周知的胃癌的危险因子，可协同增加胃癌发病的风险性，是胃癌发生的危险达11倍。
The researchers' study, headed by Dr. Yutaka Kiyohara of Kyushu University in Fukuoka City, is reported in the Dec. 15 issue of the American Journal of Epidemiology.
由福冈九州大学的Yutaka Kiyohara博士领导的该项研究发表于12月15日出版的《美国流行病学杂志》上。
The report is the latest from a long-term population-based study in Hisayama, in a populous region on the Japanese island of Kyushu. According to the 1985 census, the age and occupational distributions in Hisayama were almost identical to those in Japan as a whole.
该项新的研究是一项长期的以人口为基础的研究，是在日本九州人口最稠密的Hisayama进行的。根据1985年的人口普查，该地区的年龄和职业分布与整个日本相同。
In 1988, 2,752 Hisayama residents aged 40 years or over (more than 80% of the population in that age group) with no history of gastric cancer were screened for the present study. Because the rate of smoking was low among the women, only men, a total of 1,071, were enrolled.
1988年，2752名年龄在49岁以上，且没有胃癌史的Hisayama纳入了该项研究。由于女性吸烟比率低，该项研究仅将男性作为研究对象，共有1071人进行了调查研究。
This group was followed for 14 years, until November 2002. The frequency of cigarette smoking was 42.7% and that of H. pylori infection was 76.9%. Participants received health check-ups every 1 to 2 years, and those who moved away were followed by mail or telephone. Comprehensive efforts to identify all cases of gastric cancer in the study cohort included autopsies of 77% of those who died during the study period.
该组人群随访了14年，直到2002年12月。吸烟的比例为42.7%，HP感染者为76.9%。所有参与者每1到2年进行健康体检，那些离开该地区的被研究人员通过电子邮件或电话联系。通过广泛努力鉴定出所有胃癌病例，包括在研究其间77%死亡病例的尸检。
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作者:admin@医学,生命科学 2011-06-09 16:00
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