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【文摘发布】脂蛋白a和卒中：一项基于临床观察
Author： Smolders B, Lemmens R, Thijs V.
Resource: Stroke. 2007 Jun;38:1959-66. Epub 2007 May 3.
Abstract： BACKGROUND AND PURPOSE: The relationship between elevated lipoprotein ( a ) levels[ Lp ( a ) ] and stroke is controversial. We systematically reviewed the
literature to determine whether Lp ( a ) is a risk factor for stroke. METHODS: We
searched MEDLINE ( 1966 to 2006 ), EMBASE ( 1974 to 2006 ), and Google scholar for
articles on Lp ( a ) and cerebrovascular disease. From potentially relevant
references retrieved, we excluded uncontrolled studies, studies of children with
stroke, studies investigating carotid atherosclerosis, and studies lacking
adequate data. RESULTS: Thirty-one studies comprising 56 010 subjects with >4609
stroke events met all inclusion criteria and were included in the meta-analysis.
In case-control studies (n=23 with 2600 strokes) unadjusted mean Lp ( a ) was
higher in stroke patients (standardized mean difference, 0.39; 95% CI, 0.23 to
0.54 ) and was more frequently abnormally elevated ( OR, 2.39; 95% CI, 1.57 to
3.63 ). Sensitivity analysis and meta-regression did not find any influence of
study design, measurement period of Lp ( a ) in relationship to stroke episode,
subtype, age, and sex to explain the substantial heterogeneity between studies
(I(2)=83.7%; P<0.001 ). There was no evidence of publication bias. In nested
case-control studies (n=3 with 364 strokes) Lp ( a ) was not a risk factor for
incident stroke (OR, 1.04; 95% CI, 0.6 to 1.8). In prospective cohort studies
(n=5 with >1645 strokes), incident stroke was more frequent in patients in the
highest tertile of Lp ( a ) distribution compared with the lowest tertile of Lp ( a )
(RR, 1.22; 95% CI, 1.04 to 1.43). There was no publication bias or heterogeneity
in the prospective studies ( I(2)=0.00%; P =0.67 ). CONCLUSIONS: This meta-analysis
suggests that elevated Lp ( a ) is a risk factor for incident stroke.
PMID: 17478739 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 初译：
Title： Lipoprotein ( a ) and stroke: a meta-analysis of observational studies.
脂蛋白a和卒中：一项基于临床观察的荟萃分析
Author： Smolders B, Lemmens R, Thijs V.
Resource: Stroke. 2007 Jun;38:1959-66. Epub 2007 May 3.
Abstract： 摘要
BACKGROUND AND PURPOSE: The relationship between elevated lipoprotein ( a ) levels[ Lp ( a ) ] and stroke is controversial. We systematically reviewed the literature to determine whether Lp ( a ) is a risk factor for stroke.
背景和目的：在脂蛋白a水平升高和卒中之间的关系具有争议。我们通过系统的回顾文献确定脂蛋白a是否为卒中的危险因素。[标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-03-27 17:11
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