主页 > 医药生命 >
【文摘发布】三叉神经鞘瘤的Gamma刀治疗
Author：Jason Sheehan, Chun Po Yen, Yasser Arkha, David Schlesinger and Ladislau Steiner
Resource: J Neurosurg. May 2007 Volume 106 Number 5
Abstract：
OBJECT. Trigeminal schwannomas are rare intracranial tumors. In the past, resection and radiation therapy were the mainstays of their treatment. More recently, neurosurgeons have begun to use radiosurgery in the treatment of trigeminal schwannomas because of its successful use in the treatment of vestibular schwannomas. In this article the authors evaluate the radiological and clinical outcomes in a series of patients in whom Gamma Knife surgery (GKS) was used to treat trigeminal schwannomas.
METHODS. Twenty-six patients with trigeminal schwannomas underwent GKS at the University of Virginia Lars Leksell Gamma Knife Center between 1989 and 2005. Five of these patients had neurofibromatosis and one patient was lost to follow up. The median tumor volume was 3.96 cm3, and the mean follow-up period was 48.5 months. The median prescription radiation dose was 15 Gy, and the median prescription isodose configuration was 50%. There was clinical improvement in 18 patients (72%), a stable lesion in four patients (16%), and worsening of the disease in three patients (12%). On imaging, the schwannomas shrank in 12 patients (48%), remained stable in 10 patients (40%), and increased in size in three patients (12%). These results were comparable for primary and adjuvant GKSs. No tumor growth following GKS was observed in the patients with neurofibromatosis.
CONCLUSIONS. Gamma Knife surgery affords a favorable risk-to-benefit profile for patients harboring trigeminal schwannomas. Larger studies with open-ended follow-up review will be necessary to determine the long-term results and complications of GKS in the treatment of trigeminal schwannomas.
PMID: 尚未收录 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 初译：
Title：Gamma Knife surgery for trigeminal schwannoma.
三叉神经鞘瘤的Gamma刀治疗
Author：Jason Sheehan, Chun Po Yen, Yasser Arkha, David Schlesinger and Ladislau Steiner
Resource: J Neurosurg. May 2007 Volume 106 Number 5
Abstract：摘要：
OBJECT. Trigeminal schwannomas are rare intracranial tumors. In the past, resection and radiation therapy were the mainstays of their treatment. More recently, neurosurgeons have begun to use radiosurgery in the treatment of trigeminal schwannomas because of its successful use in the treatment of vestibular schwannomas. In this article the authors evaluate the radiological and clinical outcomes in a series of patients in whom Gamma Knife surgery (GKS) was used to treat trigeminal schwannomas.
目的：三叉神经鞘瘤是少见的颅内肿瘤。既往切除和放疗是这类疾病的主要治疗手段。最近，因为运用放射外科学手段可成功治疗前庭的神经鞘瘤，神经外科医师开始运用其治疗三叉神经鞘瘤。在这篇文章中作者评估了一组患者行Gamma刀手术治疗三叉神经鞘瘤后的放射学和临床结果。[标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-20 05:12
医学,生命科学网