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【medical-news】研究发现引起肾衰患者皮肤病变的
WINSTON-SALEM, N.C., Sept. 25 (UPI) -- A U.S. study suggests that an an enzyme is why some patients with kidney failure can develop a rare tightening and swelling of the skin and other organs.
Researchers at Wake Forest University Baptist Medical Center in Winston Salem, N.C., suggest a possible explanation for why some patients on kidney dialysis who are injected with a "contrast agent" during a magnetic resonance imaging develop nephrogenic systemic fibrosis, known as NSF.
The study, published in the October issue of the American Journal of Dermatopathology, found that an enzyme known as transglutaminase-2 may be involved. The enzyme is found throughout the body and is involved in blood clotting and wound healing.
The researchers, led by Dr. David C. Sane, hypothesized that gadolinium -- an agent injected into patient's veins during some MRI procedures to help improve the visibility of internal organs during the test -- may activate the enzyme and cause NSF.
"Compared to the healthy subjects, there was a marked increase in transglutaminase-2 in the subjects with NSF," Sane said in a statement. "This suggests that activation of transglutaminase-2 can produce the syndrome."
NSF in found in about 2 percent to 4 percent of kidney patients on dialysis who are exposed to gadolinium.
http://www.sciencedaily.com/upi/index.php?feed=Science&article=UPI-1-20070925-17510700-bc-us-kidneyskin.xml 本人认领编译本文，48小时内若未提供编译文稿，请其他战友自由认领 Enzyme may cause kidney failure skin issue
研究发现引起肾衰患者皮肤病变的一种酶
WINSTON-SALEM, N.C., Sept. 25 (UPI) -- A U.S. study suggests that an an enzyme is why some patients with kidney failure can develop a rare tightening and swelling of the skin and other organs.
温斯顿-沙伦，美国北卡罗莱纳州，9.25,合众国际社—美国一研究表明一种酶导致肾衰患者发生罕见的皮肤以及其他器官的发紧和肿胀。
Researchers at Wake Forest University Baptist Medical Center in Winston Salem, N.C., suggest a possible explanation for why some patients on kidney dialysis who are injected with a "contrast agent" during a magnetic resonance imaging develop nephrogenic systemic fibrosis, known as NSF.
温斯顿-沙伦，美国北卡罗莱纳州，美国威克森林大学浸信医学中心的研究人员解释出为什么一些在做MRI中注射过造影剂的肾透析病人会发生肾因性纤维化症，简称NSF。
The study, published in the October issue of the American Journal of Dermatopathology, found that an enzyme known as transglutaminase-2 may be involved. The enzyme is found throughout the body and is involved in blood clotting and wound healing.
美国皮肤病理学杂志10月卷研究发现，一种叫做转谷氨酰胺酶-2的酶也许参与这一病变过程。这种酶遍及全身，参与血液凝固以及伤口愈合。
The researchers, led by Dr. David C. Sane, hypothesized that gadolinium -- an agent injected into patient's veins during some MRI procedures to help improve the visibility of internal organs during the test -- may activate the enzyme and cause NSF.
由Dr. David C. Sane带领的研究小组推测钆（一种注射到患者静脉中，用来增强体内器官的在MRI过程中的可视度的金属元素）也许可以激活该酶以及引起NSF。
"Compared to the healthy subjects, there was a marked increase in transglutaminase-2 in the subjects with NSF," Sane said in a statement. "This suggests that activation of transglutaminase-2 can produce the syndrome."
“相对于健康受试者，NSF受试者的转谷氨酰胺酶-2要明显的升高，”sane阐述说。“这就表明转谷氨酰胺酶-2的激活可以导致并发症。
NSF in found in about 2 percent to 4 percent of kidney patients on dialysis who are exposed to gadolinium.
2%-4%暴露于钆的肾透析患者出现NSF并发症。 研究发现引起肾衰患者皮肤病变的一种酶
温斯顿-沙伦，美国北卡罗莱纳州，9.25,合众国际社—美国一研究表明一种酶导致肾衰患者发生罕见的皮肤以及其他器官的发紧和肿胀。
温斯顿-沙伦，美国北卡罗莱纳州，美国威克森林大学浸信医学中心的研究人员解释出为什么一些在做MRI中注射过造影剂的肾透析病人会发生肾因性纤维化症，简称NSF。
美国皮肤病理学杂志10月卷研究发现，一种叫做转谷氨酰胺酶-2的酶也许参与这一病变过程。这种酶遍及全身，参与血液凝固以及伤口愈合。
由Dr. David C. Sane带领的研究小组推测钆（一种注射到患者静脉中，用来增强体内器官的在MRI过程中的可视度的金属元素）也许可以激活该酶以及引起NSF。
“相对于健康受试者，NSF受试者的转谷氨酰胺酶-2要明显的升高，”sane阐述说。“这就表明转谷氨酰胺酶-2的激活可以导致2%-4%暴露于钆的肾透析患者出现NSF并发症。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-05 06:23
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