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【文摘发布】终末期肾病患者左室容积监测与心
Giovanni Tripepi*, Francesco Antonio Benedetto, Francesca Mallamaci*, Rocco Tripepi*, Lorenzo Malatino and Carmine Zoccali
J Am Soc Nephrol 18: 1316-1322, 2007
Left atrial volume (LAV), as indexed by height2.7, has recently emerged as an useful echocardiographic measurement to refine the estimate of cardiovascular (CV) risk in ESRD. Whether progression or regression in LAV has prognostic value in patients with ESRD is still unknown. The prognostic value for CV events of changes in LAV was tested in a cohort of 191 dialysis patients. Echocardiography was performed twice, 17 ± 2 mo apart. Changes in LAV that occurred between the second and the first echocardiographic studies were used to predict CV events during the ensuing 27 ± 13 mo. During the follow-up, there was a significant increase in LAV (from 10.5 ± 5.0 to 11.6 ± 5.6 ml/m2.7; P < 0.001). After the second echocardiographic study, 76 patients died (52 [68%] of CV causes) and 33 had nonfatal CV events. The independent association between changes in LAV and CV events was analyzed in a multiple Cox regression model taking into account a series of potential confounders, including baseline LAV and left ventricular mass and geometry. In these models, a 1-ml/m2.7 per yr increase in LAV was associated with a 12% increase in the relative risk for fatal and nonfatal CV events (P < 0.001). Changes in LAV predict incident CV events in dialysis patients independent of the corresponding baseline measurement and of left ventricular mass. Monitoring LA size by echocardiography is useful for monitoring CV risk in patients with ESRD. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 题目: 终末期肾病患者左房容积监测与心血管病风险：一项前瞻队列研究
作者:Giovanni Tripepi*, Francesco Antonio Benedetto, Francesca Mallamaci*, Rocco Tripepi*, Lorenzo Malatino and Carmine Zoccali
来源:J Am Soc Nephrol 18: 1316-1322, 2007
左房容积:高度指数2.7,近来常出现在超声心动图中,而超声心动图这种检测手段可以更加精确的评估终末期肾病患者心血管风险.对终末期肾病患者来说,左房容积的进展与逆展是否具有预后价值目前还不太清楚.对191例透析患者,用左心房容积的改变来判断心血管事件的预后.进行2次超声心动图,间隔17 ± 2 月.在接着的27 ± 13 月,第二次超声心动图与第一次超声心动图相比,左房容积的改变可以用来预测心血管事件.在随访中发现,左房容积明显增加(从10.5 ± 5.0 升到11.6 ± 5.6 ml/m2.7; P < 0.001). 第二次超声心动图检查后,76位患者死亡(其中52位患者[68%]死于心血管事件),33位患者发生了非致命的心血管事件.采用cox多元回归模型同时考虑到一系列潜在的影响因素包括左房容积的基础水平、左心室的体积和几何形态，对左房容积的变化与心血管事件之间是否具有独立的相关性进行分析.在这些模型中,左房容积a 1-ml/m2.7年增率与致命的和非致命的心血管事件危险性增加12%有相关性(P < 0.001).在透析患者,左房容积的改变可以独立于相应的左房容积基础测量（值）和左心室体积来预测心血管突发事件.对终末期肾病患者,用超声心动图检测心房容积大小来预测心血管风险是非常有价值的. indexed by height2.7?请squall老师指教!谢谢! LVM was calculated according to the Devereux formula and indexed to height2.7 (LVMI), as proposed by de Simone et al. 这是全文中的原话，因为不是超声专业，对于这个术语翻译的不太准。
17 ± 2 mo apart， 分别为17 ± 2 月 我路过。
翻译的不错。
这样翻译更好一点：
1。The independent association between changes in LAV and CV events was analyzed in a multiple Cox regression model taking into account a series of potential confounders, including baseline LAV and left ventricular mass and geometry：采用cox多元回归模型并同时参考其他一系列潜在的影响因素包括LAV的基础水平、左心室的体积和几何形态，对LAV的变化与心血管事件之间是否具有独立的相关性进行分析。
2。corresponding baseline measurement:应译为：相应的(LAV)基础测量（值）
3。17+-2mo apart，应译为：（两次echo测量）相隔17+-2个月 呵呵，自己再改一下：
The independent association between changes in LAV and CV events was analyzed in a multiple Cox regression model taking into account a series of potential confounders, including baseline LAV and left ventricular mass and geometry：采用cox多元回归模型同时考虑到一系列潜在的影响因素包括LAV的基础水平、左心室的体积和几何形态，对LAV的变化与心血管事件之间是否具有独立的相关性进行分析。 谢andrewcui战友的指点，我已经把译文重新再编辑了一下． (LAV ) 左房容积
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作者:admin@医学,生命科学 2011-06-27 01:33
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