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【文摘发布】肿瘤干细胞的靶向治疗：补充途径
Author: Lou H, Dean M
Resource: Oncogene. 2007 Feb 26;26(9):1357-60.
2005 IF: 6.872
Abstract: Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with "stem cell" characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal stem cells and have been termed "cancer stem cells". These cancer stem cells make up as few as 1% of the cells in a tumor, making them difficult to detect and study. Like normal stem cells, cancer stem cells have a number of properties permitting them to survive traditional cancer chemotherapy and radiation therapy. These cells express high levels of ATP-binding cassette (ABC) drug transporters, providing for a level of resistance; are relatively quiescent; have higher levels of DNA repair and a lowered ability to enter apoptosis. Combined cancer therapy approaches targeting the cancer stem cells and the non-stem cells may be developed with increased efficacy. Efforts to target the Hedgehog/Patched pathway, critical to embryonic growth and differentiation, and the ABCG2 drug efflux transporter will be presented.
PMID: 17322922
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Title: Targeted therapy for cancer stem cells: the patched pathway and ABC transporters.
Author: Lou H, Dean M
Resource: Oncogene. 2007 Feb 26;26(9):1357-60.
2005 IF: 6.872
Abstract: Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with "stem cell" characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal stem cells and have been termed "cancer stem cells". These cancer stem cells make up as few as 1% of the cells in a tumor, making them difficult to detect and study. Like normal stem cells, cancer stem cells have a number of properties permitting them to survive traditional cancer chemotherapy and radiation therapy. These cells express high levels of ATP-binding cassette (ABC) drug transporters, providing for a level of resistance; are relatively quiescent; have higher levels of DNA repair and a lowered ability to enter apoptosis. Combined cancer therapy approaches targeting the cancer stem cells and the non-stem cells may be developed with increased efficacy. Efforts to target the Hedgehog/Patched pathway, critical to embryonic growth and differentiation, and the ABCG2 drug efflux transporter will be presented.
PMID: 17322922
译文
Title: Targeted therapy for cancer stem cells: the patched pathway and ABC transporters.
Author: Lou H, Dean M
Resource: Oncogene. 2007 Feb 26;26(9):1357-60.
2005 IF: 6.872
肿瘤干细胞的靶向治疗：补充途径和ABC转运子
作者：Lou H, Dean M
来源：癌基因 2007，26（9）；1357-60
Abstract: Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with "stem cell" characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal stem cells and have been termed "cancer stem cells". These cancer stem cells make up as few as 1% of the cells in a tumor, making them difficult to detect and study. Like normal stem cells, cancer stem cells have a number of properties permitting them to survive traditional cancer chemotherapy and radiation therapy. These cells express high levels of ATP-binding cassette (ABC) drug transporters, providing for a level of resistance; are relatively quiescent; have higher levels of DNA repair and a lowered ability to enter apoptosis.
Combined cancer therapy approaches targeting the cancer stem cells and the non-stem cells may be developed with increased efficacy. Efforts to target the Hedgehog/Patched pathway, critical to embryonic growth and differentiation, and the ABCG2 drug efflux transporter will be presented.
PMID: 17322922
摘要：来自白血病、脑瘤与乳腺癌方面的资料显示，一小部分肿瘤细胞具有干细胞特性，具有自我更新能力。这些能够自我更新的细胞具有许多正常干细胞的特性，因此被称为“肿瘤干细胞”。肿瘤干细胞仅约占肿瘤细胞的1%，因此难于检测并被研究。象正常干细胞一样，肿瘤干细胞的许多特性确保其免于传统肿瘤化疗与放射治疗的杀伤。这些肿瘤干细胞具有如下特点：如果存在一定程度的耐受，那么该细胞往往表达高水平的ATP结合盒（ABC）药物转运体；处于相对静止状态；具有更高水平的DNA修复，并且更难于进入凋亡程序。以肿瘤干细胞和非肿瘤干细胞为治疗靶的肿瘤联合治疗方法肯可能具有更高的疗效。以对胚胎的生长与分化具有重要作用的补丁途径及ABCG2药物外排转运体为靶点的研究将迅速开展起来。
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作者:admin@医学,生命科学 2011-07-29 17:13
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