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【medical-news】胰岛素泵治疗间断不得：血糖升高
ABSTRACT
This prospective, open-label study was designed to measure the impact of short-term infusion-set disconnects on glucose levels. Continuous subcutaneous insulin infusion (CSII) therapy allows for uninterrupted delivery of insulin.
Patients disconnect their insulin pumps from their infusion sets when showering, swimming, exercising, or during intimate moments. Interrupting insulin infusion results in cessation of the basal insulin delivery. Nineteen subjects with T1DM were studied on 2 separate in-clinic days. One hour after arriving at the clinic in a fasting state, subjects either temporarily disconnected their infusion sets from their pumps, interrupting basal insulin infusion for 30 minutes, or on a separate day, only changed their infusion sets. Glucose levels were monitored for an additional 4 hours on both occasions.
Changing infusion sets did not affect short-term glucose control. However, the 30-minute interruption of basal insulin infusion resulted in significant glucose elevations; approximately 1 mg/dL for each minute basal insulin infusion was interrupted.
http://care.diabetesjournals.org/cgi/content/abstract/dc07-1757v1 Quantifying the Impact of a Short-interval interruption of Insulin-Pump Infusion Sets on Glycemic Excursions
胰岛素泵输注装置的短期中断是血糖升高的定量影响
ABSTRACT
摘要：
This prospective, open-label study was designed to measure the impact of short-term infusion-set disconnects on glucose levels. Continuous subcutaneous insulin infusion (CSII) therapy allows for uninterrupted delivery of insulin.
这是一个前瞻性的，公开的试验。试验的设计目的是测定胰岛素泵输注装置的中断对于血糖水平的影响。持续皮下胰岛素持续输注治疗考虑到了胰岛素不间断的输注。
Patients disconnect their insulin pumps from their infusion sets when showering, swimming, exercising, or during intimate moments. Interrupting insulin infusion results in cessation of the basal insulin delivery. Nineteen subjects with T1DM were studied on 2 separate in-clinic days. One hour after arriving at the clinic in a fasting state, subjects either temporarily disconnected their infusion sets from their pumps, interrupting basal insulin infusion for 30 minutes, or on a separate day, only changed their infusion sets. Glucose levels were monitored for an additional 4 hours on both occasions.
使用胰岛素泵的患者在淋浴，游泳，锻炼，或者片刻时间会中断他们的胰岛素泵持续治疗设定。胰岛素持续输注的中断会导致基础胰岛素输注的中断。19位1型糖尿病患者分开的2天内，在临床诊所进行了试验。在达到临床诊所的头一个小时是空腹状态。在这个时间，参与试验的人员分别在不同的两天中要么暂时中断胰岛素泵，间断胰岛素的注射持续30分钟，要么仅仅改变他们的胰岛素泵设定。在这两种情况中，在另外的4个小时，将观测血糖水平的变化。
Changing infusion sets did not affect short-term glucose control. However, the 30-minute interruption of basal insulin infusion resulted in significant glucose elevations; approximately 1 mg/dL for each minute basal insulin infusion was interrupted.
改变胰岛素的设定不会影响短期的血糖水平。然而，30分钟短暂的胰岛素泵持续治疗的中断却能导致血糖的显著升高，大概中断的每分钟基础胰岛素的输注量是1mg/d。
编译（共368个中文）
胰岛素泵输注装置的短期中断是血糖升高的定量影响
摘要：
这是一个前瞻性的，公开的试验。试验的设计目的是测定胰岛素泵输注装置的中断对于血糖水平的影响。持续皮下胰岛素持续输注治疗考虑到了胰岛素不间断的输注。
使用胰岛素泵的患者在淋浴，游泳，锻炼，或者片刻时间会中断他们的胰岛素泵持续治疗设定。胰岛素持续输注的中断会导致基础胰岛素输注的中断。19位1型糖尿病患者分开的2天内，在临床诊所进行了试验。在达到临床诊所的头一个小时是空腹状态。在这个时间，参与试验的人员分别在不同的两天中要么暂时中断胰岛素泵，间断胰岛素的注射持续30分钟，要么仅仅改变他们的胰岛素泵设定。在这两种情况中，在另外的4个小时，将观测血糖水平的变化。
改变胰岛素的设定不会影响短期的血糖水平。然而，30分钟短暂的胰岛素泵持续治疗的中断却能导致血糖的显著升高，大概中断的每分钟基础胰岛素的输注量是mg/d。 approximately 1 mg/dL for each minute basal insulin infusion was interrupted翻译成“大概中断的每分钟基础胰岛素的输注量是1mg/dL。 ”是不对的，应该解释为：“在基础胰岛素输注中断过程中，每分钟血糖上升大约为1mg/DL”. [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-06-16 05:14
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