主页 > 医药科学 >
【文摘发布】镰刀形红细胞贫血病人接种肺炎疫
Author: Natasha B. Halasa,1 Sadhna M. Shankar,1 Thomas R. Talbot,2,3 Patrick G. Arbogast,4,5 Ed F. Mitchel,3 Winfred C. Wang,8 William Schaffner,2,3 Allen S. Craig,3,6 and Marie R. Griffin2
Resorse: Clinical Infectious Diseases 2007;44:1428-1433
Background. We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell disease (SCD) before and after the introduction of the pneumococcal conjugate vaccine (PCV).
Methods. Individuals with SCD who were enrolled in Tennessee Medicaid from January 1995 through December 2004 were identified using SCD-specific International Classification of Diseases, Ninth Revision, Clinical Modification codes. Population-based surveillance data were used to identify individuals with IPD and were linked to patients with SCD in the Tennessee Medicaid database to determine incidence rates of IPD. Clinical data were collected on all subjects with IPD, and antibiotic susceptibility testing and serotyping were performed on all available pneumococcal isolates.
Results. We identified 2026 individuals with SCD, who constituted 13,687 person-years of follow-up. During the study period, 37 individuals with SCD developed IPD, and 21 of these patients were aged <5 years. In a comparison of the pre-PCV period (1995–1999) with the post-PCV period (2001–2004), the rate of IPD decreased by 90.8% in children aged <2 years (from 3630 to 335 cases per 100,000 person-years; P < .001) and by 93.4% in children aged <5 years (from 2044 to 134 cases per 100,000 person-years; P < .001). Rates of IPD for patients with SCD who were aged 5 years decreased from 161 cases per 100,000 person-years during the pre-PCV period to 99 cases per 100,000 person-years during the post-PCV period (P = .36).
Conclusion. The rate of IPD among children with SCD who are aged <5 years has decreased markedly since the introduction of routine administration of PCV to young children. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Title: Incidence of Invasive Pneumococcal Disease among Individuals with Sickle Cell Disease before and after the Introduction of the Pneumococcal Conjugate Vaccine
标题：镰状细胞病患者接种肺炎球菌疫苗前后侵袭性肺炎球菌疾病发病率的比较
Author: Natasha B. Halasa,1 Sadhna M. Shankar,1 Thomas R. Talbot,2,3 Patrick G. Arbogast,4,5 Ed F. Mitchel,3 Winfred C. Wang,8 William Schaffner,2,3 Allen S. Craig,3,6 and Marie R. Griffin2
作者：Natasha B等
Resorse: Clinical Infectious Diseases 2007;44:1428-1433
来源：Clinical Infectious Diseases 2007;44:1428-1433
Background. We sought to determine the incidence of invasive pneumococcal disease (IPD) among individuals with sickle cell disease (SCD) before and after the introduction of the pneumococcal conjugate vaccine (PCV).
背景：我们试寻确定镰状细胞病（SCD）患者接种肺炎球菌疫苗（PCV）前后侵袭性肺炎球菌疾病（IPD）发病率情况。
Methods. Individuals with SCD who were enrolled in Tennessee Medicaid from January 1995 through December 2004 were identified using SCD-specific International Classification of Diseases, Ninth Revision, Clinical Modification codes. Population-based surveillance data were used to identify individuals with IPD and were linked to patients with SCD in the Tennessee Medicaid database to determine incidence rates of IPD. Clinical data were collected on all subjects with IPD, and antibiotic susceptibility testing and serotyping were performed on all available pneumococcal isolates.
方法：纳入1995年1月至2004年12月田纳西州医疗补助计划的SCD患者是通过SCD特定国际疾病分类标准第九次校订的临床修正案确定的。对该群体的监察资料被用于IPD患者的鉴定，同时也连系到田纳西州医疗补助计划数据库中的SCD患者。所有IPD受试者的临床资料均被收集，对所有可得的分离肺炎球菌菌株均行抗生素药敏试验和血清分型。
Results. We identified 2026 individuals with SCD, who constituted 13,687 person-years of follow-up. During the study period, 37 individuals with SCD developed IPD, and 21 of these patients were aged <5 years. In a comparison of the pre-PCV period (1995–1999) with the post-PCV period (2001–2004), the rate of IPD decreased by 90.8% in children aged <2 years (from 3630 to 335 cases per 100,000 person-years; P < .001) and by 93.4% in children aged <5 years (from 2044 to 134 cases per 100,000 person-years; P < .001). Rates of IPD for patients with SCD who were aged 5 years decreased from 161 cases per 100,000 person-years during the pre-PCV period to 99 cases per 100,000 person-years during the post-PCV period (P = .36).
结果：我们确定了2026例SCD患者，随访人年数总计13687 。研究期间，37例出现IPD，其中21例不到5岁。PCV接种前（1995–1999）和接种后（2001–2004）相比较，2岁以下儿童IPD发病率下降了90.8%（3630例降至335例每100000人年；P < .001），5岁以下儿童下降了93.4%（2044例降至134例每100000人年；P < .001）。5岁SCD患者IPD发病率从接种PCV前的161例每100000人年降至接种后99例每100000人年（P = 0.36）。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-05-06 17:11
医学,生命科学网