主页 > 医药科学 >
【drug-news】使用病毒酶来对抗耳部感染
Viral Enzyme Recruited In Fight Against Ear Infection
Article Date: 23 Mar 2007 - 0:00 PDT
Parents might one day give their children a weekly treatment with a nasal spray of virus enzymes to prevent them from getting a severe middle ear infection, based on results of a study done in mice by investigators from St. Jude Children's Research Hospital and The Rockefeller University, in New York. Such a treatment would avoid the use of antibiotics, thus eliminating the problem of antibiotic resistance. A report on this study appears in the March issue of the online journal "PLoS Pathogens."
Middle ear infection, also called acute otitis media, is an inflammation of the middle ear space. About half of all children carry Streptococcus pneumoniae, the bacteria that cause acute otitis media. These bacteria migrate from the nose and throat to the middle ear after an initial influenza virus infection paves the way.
The investigators based their treatment on the ability of viruses called phages to break out of bacteria they infect by using a special enzyme to destroy the cell walls.
The success of the new treatment, which uses a phage enzyme called lysin to kill S. pneumonia, suggests that the strategy could significantly reduce the incidence of acute otitis media in the United States. More than 24 million cases are now diagnosed each year, despite the use of vaccines against S. pneumoniae.
"Lysin also appears to hold promise for preventing the secondary pneumonia caused when a person infected with S. pneumoniae is subsequently infected with the influenza virus, said Jonathan McCullers, M.D., associate member in the Infectious Diseases department at St. Jude. McCullers is first author of the "PLoS" paper.
The investigators demonstrated that lysin can eliminate these bacteria from the ear using mice developed at St. Jude that represented the first such model in which acute otitis media develops in a similar way that it develops the disease in children. The mice were treated by purified lysin that was prepared in the laboratory of Vincent A. Fischetti, Ph.D., a professor and co- head of the Laboratory of Bacterial Pathogenesis and Immunology at The Rockefeller University. He was assisted by Jutta M. Loeffler, postdoctoral associate. Fischetti is senior author of the "PLoS" paper.
"The nasal spray may eventually be used weekly during flu season to keep a person free of Streptococcus pneumoniae or after infection with the flu virus," said Fischetti. "This might truly be a case in which an ounce of prevention would be worth a pound of cure."
Other St. Jude authors of this paper include Asa Karlstrom and Amy R. Iverson (St. Jude).
This work was supported in part by the United States Public Health Service and ALSAC. http://www.medicalnewstoday.com/medicalnews.php?newsid=65864
Viral Enzyme Recruited In Fight Against Ear Infection
抵御耳部感染的新成员—病毒酶
Article Date: 23 Mar 2007 - 0:00 PDT
Parents might one day give their children a weekly treatment with a nasal spray of virus enzymes to prevent them from getting a severe middle ear infection, based on results of a study done in mice by investigators from St. Jude Children's Research Hospital and The Rockefeller University, in New York. Such a treatment would avoid the use of antibiotics, thus eliminating the problem of antibiotic resistance. A report on this study appears in the March issue of the online journal "PLoS Pathogens."
有一天父母可能会给他们的孩子使用一种病毒酶的鼻腔喷雾进行每周一次治疗以预防重度中耳感染，这是由纽约的St. Jude儿童研究医院与Rockefeller大学得研究人员以对小鼠的研究为基础得到的结果。这样一种治疗将避免使用抗生素，从而可以减少抗生素耐药的问题。关于该研究的报道出现在三月版的“PLoS Pathogens”杂志的网站上。
Middle ear infection, also called acute otitis media, is an inflammation of the middle ear space. About half of all children carry Streptococcus pneumoniae, the bacteria that cause acute otitis media. These bacteria migrate from the nose and throat to the middle ear after an initial influenza virus infection paves the way.
中耳感染，也称为急性中耳炎，是中耳腔的一种炎症。大约有一半儿童都携带肺炎链球菌，这种细菌可以引起急性中耳炎。一种原发流感病毒感染之后，可以使这些细菌从鼻和咽喉移行至中耳。
The investigators based their treatment on the ability of viruses called phages to break out of bacteria they infect by using a special enzyme to destroy the cell walls.
研究人员把他们的治疗建立在一种能够破坏称为噬菌体的病毒之上，其可以利用一种特殊的酶感染破坏细胞壁。
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-01-11 17:14
医学,生命科学网