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【medical-news】染色体17的变异影响前列腺癌和II型
路透健康根据自然遗传学杂志最新网络报告
NEW YORK (Reuters Health) - Two variants in chromosome 17 influence prostate cancer, and one of these also influences the risk for type 2 diabetes, according to a report in the July 1st advance online publication of Nature Genetics.
The long arm of chromosome 17 has previously been associated with prostate cancer in family-based linkage studies, the authors explain, but no susceptibility variants have been reported before now.
Dr. Kari Stefansson, from deCODE Genetics, Reykjavik, Iceland, and colleagues analyzed six single nucleotide polymorphisms (SNPs) on chromosome 17q that showed some association with prostate cancer in their genome-wide analysis.
Two SNPs showed significant association with prostate cancer, with allele A of rs4430796 conferring a 22% increased risk and allele G of rs1859962 conferring a 20% increased risk.
SNP rs4430796 is located in the second intron of the TCF2 gene, the authors report, whereas rs1859962 is in a gene-poor area on 17q24.3.
Allele A of SNP rs4430796 also showed a protective effect against type 2 diabetes, the researchers note, affording a 14% reduced risk.
SNP rs4430796 was substantially correlated with another SNP in the first intron of TCF2 (rs7501939), whose allele C conferred a similar risk increase for prostate cancer and protection against type 2 diabetes.
"Together, based on the combined results, these two variants have an estimated joint population attributable risk of about 36%, which is substantial from a public health viewpoint," the investigators write.
"We favor the notion that the primary functional impact of rs4430796 (or a presently unknown correlated variant) is on one or more metabolic or hormonal pathways important for the normal functioning of individuals throughout their lives that incidentally modulate the risk of developing prostate cancer and type 2 diabetes late in life," the researchers note.
Nature Genetics 2007. 没人。我来玩一会儿。
染色体17变异影响前列腺癌、2型糖尿病的危险性
Chromosome 17 variants influence prostate cancer, type 2 diabetes risk
路透健康根据自然遗传学杂志最新网络报告
纽约（路透社）－根据Nature Genetics 7月1日在网上提起发表的一份报告，染色体17中的2个变异影响前列腺癌，其中的一个也影响2型糖尿病。
NEW YORK (Reuters Health) - Two variants in chromosome 17 influence prostate cancer, and one of these also influences the risk for type 2 diabetes, according to a report in the July 1st advance online publication of Nature Genetics.
作者说，17号染色体的长臂以前在家族相关性研究中（被认为）与前列腺癌有关，但是以前没有报道易感变异。
The long arm of chromosome 17 has previously been associated with prostate cancer in family-based linkage studies, the authors explain, but no susceptibility variants have been reported before now.
deCODE Genetics, Reykjavik, Iceland的Dr. Kari Stefansson和同事分析了17号染色体q（长臂）上的6个SNPs（单核苷酸多态性），显示与他们的基因组范围分析的前列腺癌有一定相关。
Dr. Kari Stefansson, from deCODE Genetics, Reykjavik, Iceland, and colleagues analyzed six single nucleotide polymorphisms (SNPs) on chromosome 17q that showed some association with prostate cancer in their genome-wide analysis.
2个SNPs显示与前列腺癌明显相关，rs4430796（什么意思？）的位点A可增加危险性22％，rs1859962的位点G可增加危险性20％。
Two SNPs showed significant association with prostate cancer, with allele A of rs4430796 conferring a 22% increased risk and allele G of rs1859962 conferring a 20% increased risk.
作者报告，SNP rs4430796定位在TCF2基因的第二个内含子，而rs1859962定位在17号染色体长臂24.3的少基因区。
SNP rs4430796 is located in the second intron of the TCF2 gene, the authors report, whereas rs1859962 is in a gene-poor area on 17q24.3.
谁来继续。。。。。。
Allele A of SNP rs4430796 also showed a protective effect against type 2 diabetes, the researchers note, affording a 14% reduced risk.
SNP rs4430796 was substantially correlated with another SNP in the first intron of TCF2 (rs7501939), whose allele C conferred a similar risk increase for prostate cancer and protection against type 2 diabetes.
"Together, based on the combined results, these two variants have an estimated joint population attributable risk of about 36%, which is substantial from a public health viewpoint," the investigators write.
"We favor the notion that the primary functional impact of rs4430796 (or a presently unknown correlated variant) is on one or more metabolic or hormonal pathways important for the normal functioning of individuals throughout their lives that incidentally modulate the risk of developing prostate cancer and type 2 diabetes late in life," the researchers note.
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作者:admin@医学,生命科学 2011-02-25 17:12
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