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经皮肝脏活检碎片与纤维化程度之间的相关性
186例患者前瞻性进行经皮肝脏活检，并检测标本的碎片长度和数量。病理医生在不知晓临床资料的情况下，对纤维化程度进行评分。比较不同分期的碎片长度和破碎资料。
结果显示，全部碎片的平均长度为1.85cm，平均碎片数目为4个。晚期纤维化（Ⅲ～Ⅳ期）标本的碎片数目多于无或轻度纤维化（0～Ⅱ期）标本（P<0.0001）。随着纤维化分期的增加，总碎片长度降低（P<0.0001）。仅有晚期纤维化标本的碎片数目多于12个。
Malik博士等认为，经皮肝活检标本经常出现破碎，碎片随纤维化由早期至晚期的进展而增多。纤维化标本的碎片更常见，并且更广泛。
Correlation of percutaneous liver biopsy fragmentation with the degree of fibrosis.
BACKGROUND: : Although fragmentation of a liver biopsy specimen has been considered to be suggestive of cirrhosis, the evidence for this is difficult to find in the published literature. AIM: : To determine whether fragmentation of percutaneous liver biopsy specimens correlates with the degree of fibrosis.
METHODS: : One hundred and eighty-six patients underwent percutaneous liver biopsy prospectively. The specimens were measured for the length and number of fragments. The extent of fibrosis was scored by a pathologist blind to the clinical data. Length and fragmentation data were compared between the different stages.
RESULTS: The overall median fragment length was 1.85 cm and the median fragment number was four. Specimens with advanced fibrosis (stages III-IV) had more fragments than those with no or mild fibrosis (stages 0-II) (P < 0.0001). The aggregate fragment length decreased with increasing stage of fibrosis (P < 0.0001). Specimens with greater than 12 fragments were seen only with advanced fibrosis.
CONCLUSIONS: : Fragmentation of percutaneous liver biopsy specimens is common and increases with progression from early to advanced fibrosis. Fibrotic specimens fragment more often and more extensively.
Aliment Pharmacol Ther. 2004 Mar;19(5):545-9. [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-02-25 17:12
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