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【medical-news】《Dibetes》：触珠蛋白是1型糖尿病者
Objective: Haptoglobin (Hp) is a plasma protein that binds free hemoglobin, thereby inhibiting hemoglobin-induced oxidative damage. We investigated the association between the Hp genotype and the incidence of coronary artery disease (CAD) in a cohort of individuals with childhood-onset type 1 diabetes.
Research Design and Methods: Participants from the Epidemiology of Diabetes Complications Study who were free of CAD at study entry and had DNA available were selected (n=453; mean age, 27.1 years and diabetes duration, 18.8 years). CAD was defined as angina, ischemic electrocardiogram, myocardial infarction confirmed by Q-waves on electrocardiogram or hospital records, angiographic stenosis >50%, or revascularization.
Results: The proportions of the cohort with the Hp 1/1, 2/1 and 2/2 genotypes were 11.5%, 41.3% and 47.2%, respectively. During 18 years of follow-up, there were 135 (29.8%) incident CAD events. Univariately, the proportion of CAD events increased from 15.4% (Hp 1/1), to 28.3% (Hp 2/1) and 34.6% (Hp 2/2) (p=0.02, p-trend=0.007). Cumulative incidence (including 33 baseline prevalent cases) also increased from 24.1% (Hp 1/1), to 32.3% (Hp 2/1), and 39.1% (Hp 2/2) (p=0.07, p-trend=0.02). In Cox proportional hazards models adjusting for traditional CAD risk factors, the Hp 2/2 genotype was associated with increased CAD incidence compared to the Hp1/1 genotype (HR=2.21, 95% CI=1.05-4.65, p-value=0.04). Although the risk associated with the Hp 2/1 genotype did not reach significance (HR=1.78, 95% CI=0.84-3.79, p-value=0.13), there remained a significant trend across the three groups (p=0.03).
Conclusions: These data support the hypothesis that the Hp genotype influences cardiovascular risk in type 1 diabetes.
http://diabetes.diabetesjournals.org/cgi/content/abstract/db08-0095v1
作者及其单位
Tina Costacou, Ph.D.1, Robert E. Ferrell, Ph.D.2, and Trevor J. Orchard, M***h, MMedSci.1
1Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
2Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 试着翻译一下医学方面的文章。
Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes
遗传型触珠蛋白：1型糖尿病心血管并发症风险因素
Objective: Haptoglobin (Hp) is a plasma protein that binds free hemoglobin, thereby inhibiting hemoglobin-induced oxidative damage. We investigated the association between the Hp genotype and the incidence of coronary artery disease (CAD) in a cohort of individuals with childhood-onset type 1 diabetes.
目的：触珠蛋白是一种能与游离的血红蛋白结合的血浆蛋白，因而抑制血红蛋白诱导的氧化破坏。我们研究了患儿童期初发型1型糖尿病人中遗传型触珠蛋白和发生冠心病（CAD）之间的关系。
Research Design and Methods: Participants from the Epidemiology of Diabetes Complications Study who were free of CAD at study entry and had DNA available were selected (n=453; mean age, 27.1 years and diabetes duration, 18.8 years). CAD was defined as angina, ischemic electrocardiogram, myocardial infarction confirmed by Q-waves on electrocardiogram or hospital records, angiographic stenosis >50%, or revascularization.
研究设计和方法：入选糖尿病并发症流行病学研究的参与者起初不患有CAD，并且病人的DNA可以获得（n=453，平均年龄27.1岁，患病时间18.8年）。CAD被定义为心绞痛、心肌缺血、ECG的Q波或医院诊断的心肌梗塞、血管狭窄>50%，或者血管再生。
Results: The proportions of the cohort with the Hp 1/1, 2/1 and 2/2 genotypes were 11.5%, 41.3% and 47.2%, respectively. During 18 years of follow-up, there were 135 (29.8%) incident CAD events. Univariately, the proportion of CAD events increased from 15.4% (Hp 1/1), to 28.3% (Hp 2/1) and 34.6% (Hp 2/2) (p=0.02, p-trend=0.007). Cumulative incidence (including 33 baseline prevalent cases) also increased from 24.1% (Hp 1/1), to 32.3% (Hp 2/1), and 39.1% (Hp 2/2) (p=0.07, p-trend=0.02). In Cox proportional hazards models adjusting for traditional CAD risk factors, the Hp 2/2 genotype was associated with increased CAD incidence compared to the Hp1/1 genotype (HR=2.21, 95% CI=1.05-4.65, p-value=0.04). Although the risk associated with the Hp 2/1 genotype did not reach significance (HR=1.78, 95% CI=0.84-3.79, p-value=0.13), there remained a significant trend across the three groups (p=0.03).
结果：患者中Hp1/1、2/1和2/2型所占的比例分别为11.5%，41.5%和47.2%。经过18年的随访期，有135人（29.8%）患上CAD。单变量分析，CAD事件发生的概率依次为15.4%(Hp 1/1), 28.3% (Hp 2/1) 和39.1% (Hp 2/2) (p=0.07, p-trend=0.02)，呈递增趋势。应用Cox比例风险模型分析传统CAD风险因子，与Hp1/1相比，Hp 2/2型增加CAD事件的发生率(HR=2.21, 95% CI=1.05-4.65, p-value=0.04)。尽管风险与Hp 2/1型的关系尚不显著(HR=1.78, 95% CI=0.84-3.79, p-value=0.13),但从三组的结果看，仍呈现出明显的趋势(p=0.03)。
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作者:admin@医学,生命科学 2011-02-12 17:14
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