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【文摘发布】Sjogren's综合征患者角膜病变的活体
Villani E, Galimberti D, Viola F, Mapelli C, Ratiglia R.
Clinica Oculistica Universita degli Studi di Milano, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS (Istituti di Ricovero e Cura a Carattere Scientifico), Milan, Italy.
PURPOSE: To analyze the in vivo morphology of corneal cells and nerves in dry eye associated with primary (SSI) and secondary (SSII) Sjogren's syndrome and to study its relationship with the clinical evaluation. METHODS: Thirty-five patients with SS and 20 age- and gender-matched control subjects were studied. Confocal microscopy was used to investigate corneal thickness, epithelial and stromal cellular density, and subbasal plexus morphology. RESULTS: Corneal central thickness was 514.74 +/- 19.85 mum in the SS group and 550 +/- 21.46 mum in the control group (P < 0.0001, t-test); stromal central thickness was 456.62 +/- 18.05 mum in the SS group and 487.35 +/- 20.40 mum in the control group (P < 0.0001). The density of the superficial epithelial cells in the SSI and SSII groups was 965.40 +/- 96.00 and 999.80 +/- 115.67 cells/mm(2), respectively, and 1488.55 +/- 133.74 cells/mm(2) in the control group (P < 0.001, ANOVA). The number of subbasal nerves was 3.34 +/- 0.76 in the SS group and 5.10 +/- 0.79 in the control group (P < 0.0001, t-test). The average grade of nerve tortuosity was 2.62 +/- 0.94 in the SS group and 1.20 +/- 0.70 in the control group (P < 0.0001). Statistically significant correlations were found between clinical data and confocal microscopy data. CONCLUSIONS: Corneal thickness, cells, and nerves show morphologic changes in patients with dry eye associated with SS. The in vivo confocal study of these alterations may be important in better understanding the complexity of the ocular surface morphofunctional unit and the potentials of therapeutic approaches for the control of the phlogistic process and neuroprotection.
PMID: 17460255 [PubMed - in process]
Invest Ophthalmol Vis Sci. 2007 May;48(5):2017-22 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 The Cornea in Sjogren's Syndrome: An In Vivo Confocal Study.
干燥综合症患者角膜病变的活体共聚焦显微镜研究Sjogren's综合征患者角膜病变的活体共Villani E, Galimberti D, Viola F, Mapelli C, Ratiglia R.
Clinica Oculistica Universita degli Studi di Milano, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS (Istituti di Ricovero e Cura a Carattere Scientifico), Milan, Italy.
PURPOSE: To analyze the in vivo morphology of corneal cells and nerves in dry eye associated with primary (SSI) and secondary (SSII) Sjogren's syndrome and to study its relationship with the clinical evaluation.
目的：分析原发性和继发性干燥综合症综合症干眼患者的角膜细胞和神经形态学的变化，及其与临床评价的关系。
METHODS: Thirty-five patients with SS and 20 age- and gender-matched control subjects were studied.
方法：35个干燥综合症患者和20个年龄和性别相匹配的对照组
Confocal microscopy was used to investigate corneal thickness, epithelial and stromal cellular density, and subbasal plexus morphology.
用共聚焦显微镜来研究角膜的厚度，上皮细胞和间质细胞的密度以及基质浅丛的形态。
RESULTS: Corneal central thickness was 514.74 +/- 19.85 mum in the SS group and 550 +/- 21.46 mum in the control group (P < 0.0001, t-test); stromal central thickness was 456.62 +/- 18.05 mum in the SS group and 487.35 +/- 20.40 mum in the control group (P < 0.0001).
结果：角膜中央的厚度在干燥综合症患者中约为514.74+/ -19.85mum，而对照组中为550 +/- 21.46 mum（(P < 0.0001，t检验）；间质中央厚度在干燥综合症患者约为456.62 +/- 18.05 mum，在对照组中487.35 +/- 20.40 mum（(P < 0.0001）
The density of the superficial epithelial cells in the SSI and SSII groups was 965.40 +/- 96.00 and 999.80 +/- 115.67 cells/mm(2), respectively, and 1488.55 +/- 133.74 cells/mm(2) in the control group (P < 0.001, ANOVA).
浅表上皮细胞的密度在原发性和继发性干燥综合症分别为为965.40 +/- 96.00和d 999.80 +/- 115.67细胞/平方厘米，在对照组中为则为1488.55 +/- 133.74细胞/平方厘米（(P < 0.001，方差分析）。
The number of subbasal nerves was 3.34 +/- 0.76 in the SS group and 5.10 +/- 0.79 in the control group (P < 0.0001, t-test).
基底下的神经纤维的数量在干眼综合症患者中为3.34 +/- 0.76，对照组中为5.10 +/- 0.79。（P < 0.0001，t检验）。
The average grade of nerve tortuosity was 2.62 +/- 0.94 in the SS group and 1.20 +/- 0.70 in the control group (P < 0.0001).
干燥综合症组中神经迂曲度平均分级为2.62 +/- 0.94，在对照组中为1.20 +/- 0.70(P < 0.0001)。
Statistically significant correlations were found between clinical data and confocal microscopy data.
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作者:admin@医学,生命科学 2011-02-15 05:12
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