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【drug-news】研究显示普通止痛药能增加血压
Common painkillers can raise blood pressure: study
Older men face hypertension risk with acetaminophen, ibuprofen, aspirin
Last Update: 4:06 PM ET Feb 26, 2007
BOSTON (MarketWatch) -- Older men who frequently use three of the most popular over-the-counter pain relievers face a heightened risk of developing high blood pressure, a new medical study shows.
According to researchers at Boston's Brigham & Women's Hospital, the study showed that men who frequently took such widely used pain killers as aspirin, ibuprofen and acetaminophen had up to a 38% increased risk of developing high blood pressure.
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"This is important because acetaminophen, ibuprofen and aspirin are the three most commonly used drugs in the U.S., and high blood pressure affects about 60 million Americans," said the hospital's Dr. John Forman, author of the study, in an e-mail interview. "High blood pressure is one of the leading causes of heart disease and death."
Forman said he did not want to comment on whether the Food and Drug Administration should have the drugs carry warning labels advising of the risk, stating that was a public-policy issue.
The study found the highest risk was associated with a group of pain relievers known as non-steroidal anti-inflammatory drugs, or NSAIDs, which include ibuprofen and naproxen. Ibuprofen is also marketed under the brand names Advil, Motrin and Nuprin. Naproxen can be found under the names Aleve and Naprosyn.
Men who used NSAIDs six or seven times a week showed a 38% increased risk of developing hypertension, the researchers found.
Acetaminophen users had the next highest risk, with an increased hypertension rate of 34% when the drug was used six to seven times a week. Acetaminophen is also marketed under the brand names Tylenol and Panadol.
Acetaminophen and nonsteroidal anti-inflammatory drugs already have warnings advising caution when taken by patients who drink three or more alcoholic drinks per day.
Aspirin, which is commonly prescribed to patients at risk of suffering a heart attack because of its blood-thinning properties, also carried a risk. Men who used the medication six to seven times a week exhibited a 26% increased risk of developing high blood pressure.
The results were based on an analysis of data collected from 2000 through 2004 on men with a median age of 65 and no history of hypertension who were taking the medications. Of the 16,031 men analyzed, 1,968 developed high blood pressure. The data is part of a larger ongoing study started by the hospital in 1986 that is tracking the health patterns of male medical professionals.
Any elevation can be harmful
The study did not measure to what degree the men's blood pressure was raised or whether the symptoms subsided once they stopped taking the drugs, said Forman.
"That being said, it is well established that even small increases in blood pressure translate into significant increases in risk of cardiovascular death and disease," said Forman. "Therefore, 'slightly' elevated blood pressure is also dangerous."
Despite the findings, Forman noted that the drugs are still a valuable medical option.
"While we are highlighting certain potential risks, these medications also have benefits, including pain control, and in the case of aspirin for some people, reduction in heart-attack risk," said Forman.
"Patients and their clinicians should make informed choices," Forman added.
Results of the study will be published in the Feb. 26 issue of the Archives of Internal Medicine, a publication of the American Medical Society. The research was funded by the American Heart Association and the National Institutes of Health.
Val Brickates Kennedy is a reporter for MarketWatch in Boston. 48小时认领 人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Common painkillers can raise blood pressure: study
研究显示普通止痛药能增加血压 Older men face hypertension risk with acetaminophen, ibuprofen, aspirin 老年人服用对乙氨基酚，布洛芬，阿司匹林有高血压风险 Last Update: 4:06 PM ET Feb 26, 2007 上次更新：4：06 下午 2007-2-26 BOSTON (MarketWatch) -- Older men who frequently use three of the most popular over-the-counter pain relievers face a heightened risk of developing high blood pressure, a new medical study shows.
波士顿（市场观察）-老年人经常服用三种常见的非处方止痛药会增加患有高血压的风险，一项新的医疗调查研究显示。 According to researchers at Boston's Brigham & Women's Hospital, the study showed that men who frequently took such widely used pain killers as aspirin, ibuprofen and acetaminophen had up to a 38% increased risk of developing high blood pressure. 波士顿布莱根妇女医院的研究者发现，男性经常服用常见止痛药阿司匹林，对乙氨基酚，布洛芬患有高血压风险会增加38%。 Check out Personal Finance 检查个人经济状况 From real estate to retirement, MarketWatch covers the topics that are vital to your pocketbook. Don't miss these recent winners: 从房地产到退休，市场观察含有你所关心的任何话题 "This is important because acetaminophen, ibuprofen and aspirin are the three most commonly used drugs in the U.S., and high blood pressure affects about 60 million Americans," said the hospital's Dr. John Forman, author of the study, in an e-mail interview. "High blood pressure is one of the leading causes of heart disease and death."
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作者:admin@医学,生命科学 2011-02-13 17:11
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