主页 > 医药科学 >
【medical-news】BRCA1 和 BRCA2突变与癌症之间有着更
More Common Associations Found Between BRCA1 And BRCA2 Mutations And Cancer
BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular, and pancreatic cancers, according to a study in the December 6 issue of the Journal of the National Cancer Institute.
Mutations in the BRCA1 and BRCA2 genes are known to lead to breast and ovarian cancer. However, the frequency of these mutations in the general population has not been well-characterized.
Harvey A. Risch, M.D., Ph.D., of the Yale University School of Medicine in New Haven, Conn., and colleagues looked for BRCA1 and BRCA2 mutations in 1,171 ovarian cancer patients from Ontario who were diagnosed between 1995 and 1999. They examined cancer outcomes in the patients' 8,680 first-degree relatives.
The authors found that 13.2% of the ovarian cancer patients had BRCA1 or BRCA2 mutations compared with 0.32% for BRCA1 mutations and 0.69% for BRCA2 mutations in the general Ontario population. BRCA1 mutations in the general Ontario population were associated with higher risk of ovarian, female breast, and testicular cancers. BRCA2 mutations in the general Ontario population were associated with higher risks of male and female breast, ovarian, and pancreatic cancer. They estimated that about 1% of people in the general Ontario population carried these mutations, which is much higher than had been previously thought.
"BRCA1 and BRCA2 mutations should be suspected in families with breast, ovarian, and various other cancers in male relatives as well as female," the authors write.
In an accompanying editorial, Kenneth Offit, M.D., of Memorial Sloan-Kettering Cancer Center, writes that the implications for doctors and patients remain unchanged. The prevalence of BRCA2 mutations associated with ovarian cancer "still warrants consideration of risk-reducing surgery, albeit at a somewhat older age than that recommended for BRCA1 mutation carriers. "BRCA mutation status remains one of the strongest markers for risk of this disease, warranting increased surveillance with such modalities as magnetic resonance imaging, hormonal and other chemoprevention, and, in selected circumstances, preventive surgery." 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 More Common Associations Found Between BRCA1 And BRCA2 Mutations And Cancer
BRCA1和BRCA2突变与癌症关系更加密切
BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular, and pancreatic cancers, according to a study in the December 6 issue of the Journal of the National Cancer Institute.
根据美国国家癌症研究所杂志12月6日版的一篇研究报告，BRCA1和BRCA2突变在一般人群中可能比以往报道的更加普遍，可能与卵巢、乳房、睾丸、胰腺癌关联。
Mutations in the BRCA1 and BRCA2 genes are known to lead to breast and ovarian cancer. However, the frequency of these mutations in the general population has not been well-characterized.
熟知BRCA1 和BRCA2基因突变可引起乳癌和卵巢癌，不过在普通人群中突变的频率还没有很好地描述。
Harvey A. Risch, M.D., Ph.D., of the Yale University School of Medicine in New Haven, Conn., and colleagues looked for BRCA1 and BRCA2 mutations in 1,171 ovarian cancer patients from Ontario who were diagnosed between 1995 and 1999. They examined cancer outcomes in the patients' 8,680 first-degree relatives.
美国耶鲁大学医学院Harvey A. Risch博士及其同事对安大略省1995-1999年诊断为卵巢癌的1171例患者，进行BRCA1和BRCA2突变的研究，他们研究了患者8680例一级亲属的癌症发生情况。
The authors found that 13.2% of the ovarian cancer patients had BRCA1 or BRCA2 mutations compared with 0.32% for BRCA1 mutations and 0.69% for BRCA2 mutations in the general Ontario population. BRCA1 mutations in the general Ontario population were associated with higher risk of ovarian, female breast, and testicular cancers. BRCA2 mutations in the general Ontario population were associated with higher risks of male and female breast, ovarian, and pancreatic cancer. They estimated that about 1% of people in the general Ontario population carried these mutations, which is much higher than had been previously thought.
作者发现，13.2%卵巢癌患者有BRCA1和BRCA2突变，而安大略省普通人群仅有0.32%发生BRCA1突变，0.69%BRCA2突变。安大略省普通人群BRCA1突变与卵巢癌、女性乳癌、睾丸癌的高风险相关。BRCA2突变与男女乳癌、卵巢癌、胰腺癌的高风险相关。他们估计，约1%安大略省普通人群携带这些突变基因，它比先前认为的要高得多。
"BRCA1 and BRCA2 mutations should be suspected in families with breast, ovarian, and various other cancers in male relatives as well as female," the authors write.
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-02-13 17:11
医学,生命科学网