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【medical-news】阳光维生素治疗前列腺癌
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Sunshine Vitamin For Prostate Cancer
Main Category: Prostate News
Article Date: 23 Aug 2006 - 0:00am (PDT)
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Relaxing in the bright sunshine on a warm autumn day does more than lift your spirits; it also stimulates your body to produce huge amounts of vitamin D. Often called the “sunshine vitamin,” vitamin D is not really a vitamin at all, but rather a versatile hormone produced by the body in response to sunlight.
When a person is exposed to the sun, a cascade of chemical reactions begins in the skin and converts vitamin D produced in the skin into the active form of vitamin D through further modification in the liver and kidneys. Researchers have known for a long time that vitamin D helps the body absorb calcium to build strong bones and teeth. Vitamin D also helps to strengthen the immune system and seems to protect against some types of cancers and as well as other diseases. Scientists and researchers worldwide are working to understand and capitalize on the process to prevent and/or treat as many as 17 types of cancer.
Evidence of vitamin D's protective effect against cancer is compelling. Regular sun exposure is associated with lower mortality rates from certain kinds of cancers. Some studies indicate that vitamin D may help prevent cancer of the breast, colon, ovaries and prostate. A recent report indicated those individuals with higher levels of vitamin D in the blood had as much as a 50% lower cancer risk of many types for cancer.
Currently scientists at Roswell Park Cancer Institute, under the direction of Donald Trump, MD, Associate Director, and Candace Johnson, PhD, Senior Vice President for Translational Research are analyzing vitamin D in cancer prevention and treatment. Their focus is on the most potent form of vitamin D - calcitriol - which has many roles in how the body's immune system reacts to challenges and how cancer cells grow.
In the laboratory, scientists are examining the molecular and vascular mechanisms of vitamin D to help define how to make the vitamin more effective in fighting disease. In the clinics, studies are trying to determine if linking calcitriol with chemotherapy will be a new treatment option for patients diagnosed with advanced prostate cancer. Dr. Trump has significant experience with the clinical aspects of vitamin D in the treatment of solid tumors and has performed more clinical trials in cancer with vitamin D than anyone else in the world.
阳光维生素（维生素D，译者注）治疗前列腺癌
在一个温暖的秋天里在明媚的阳光下放松胜过你的精神解脱，这还能刺激你的身体产生大量维生素D。通常称作“阳光维生素”的维生素D并不是真正的维生素，更确切地说是一种身体接受阳光照射而反应性产生的多功能激素。
当人暴露在阳光下时，皮肤内部开始发生一系列连锁化学反应，转化生成维生素D，然后在肝脏和肾脏内经过进一步修饰转化成维生素D的活性形式。很久以来研究员就知道维生素D能帮助人体吸收钙来构建坚硬的骨骼和牙齿。维生素D还能帮助加强人的免疫系统，似乎能防止某些癌症和其他一些疾病的发生。全世界的科学家和研究员正在探索并利用这种方法去预防和治疗多达17种癌症。
维生素D对癌症具有保护效应的证据是令人不得不服的。规则的日照和某几种癌症的死亡率降低具有联系。一些研究表明维生素D可能能够预防的癌症有乳腺癌，结肠癌，卵巢癌和前列腺癌。一份最近的报告显示具有高血维生素D水平的个体患多种癌症的风险降低达50％。
最近，Roswell Park癌症研究所的科学家们在副主任Donald Trump医学博士和负责Translational研究的高级副总裁Candace Johnson博士的带领下，正在分析维生素D对癌症的预防和治疗。他们的焦点集中在维生素最有效的形式1,25-二羟胆钙化醇上，它在机体免疫系统对刺激的反应以及癌细胞生长中具有多种效应。
在实验室里，科学家正在通过研究维生素的分子和血管机制来帮助阐明如何使维生素与疾病作斗争的作用变得更加有效。在临床上，研究试图阐明对被诊断为早期前列腺癌的病人，结合1,25-二羟胆钙化醇的化学治疗是否能成为一种新的治疗选择。Trump博士已经在维生素D治疗实体瘤的临床方面积累了有用的经验，并且在维生素D治疗癌症方面做的临床研究比全世界其他人都多。 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-09-18 05:14
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