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【Stem Cell】Cell Stem Cell：干细胞治疗失明
华盛顿大学结构生物学系的研究科学家将来源于人类胚胎干细胞的视网膜祖细胞通过眼球注射注入到小鼠的眼内，视网膜祖细胞会主动移行至小鼠眼睛的视网膜上，祖细胞在视网膜上逐渐适应找到适宜的环境，并开始分化成rod和cone感光细胞（也就是光感受器）。将这些祖细胞移植到成年Crx小鼠（利伯（氏）先天性黑曚疾病模型）的视网膜下间隙，有胚胎干细胞衍生的视网膜祖细胞进入后开始分化成感光细胞并开始恢复小鼠对光线的感受功能。
这些结果表明，干细胞疗法可以作为治疗利伯（氏）先天性黑曚疾病的有效手段。
Cell Stem Cell, 9 January 2009 doi:10.1016/j.stem.2008.10.015
Transplantation of Human Embryonic Stem Cell-Derived Photoreceptors Restores Some Visual Function in Crx-Deficient Mice
Deepak A. Lamba1,Juliane Gust1andThomas A. Reh1,,
1 Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
SUMMARY
Some of the most common causes of blindness involvethe degeneration of photoreceptors in the neural retina; photoreceptor replacement therapy might restore some vision in these individuals. Embryonic stem cells (ESCs) could, in principle, provide a source of photoreceptors to repair the retina. We have previously shown that retinal progenitors can be efficiently derived from human ESCs. We now show that retinal cells derived from human ESCs will migrate into mouse retinas following intraocular injection, settle into the appropriate layers, and express markers for differentiated cells, including both rod and cone photoreceptor cells. After transplantation of the cells into the subretinal space of adult Crx/ mice (a model of Leber's Congenital Amaurosis), the hESC-derived retinal cells differentiate into functional photoreceptors and restore light responses to the animals. These results demonstrate that hESCs can, in principle, be used for photoreceptor replacement therapies. 不知道什么时候能用于临床啊 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-06 17:11
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