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【drug-news】抗血栓新药物
The cellular response to Viagra may be harnessed to help create new anticoagulant therapies, according to an article released on August 26, 2008 in the Proceedings of the National Academy of Sciences (PNAS.)
The enzyme PDE5 is known to modulate platelet activity. Normally, platelets exist in the blood and have an integral role in blood clotting. However, when patient have certain biomedical devices implanted, such as stents, which are installed in the arteries to maintain blood flow through them, the foreign materials of the devices , are recognized by the body and platelets often clot to them. If too many clot, this can block blood flow, potentially inducing a stroke or heart attack.
While Viagra is most famous for its use in treatment of erectile dysfunction, it was initially targeted as a drug for the cardiovascular system as a whole and is also used to treat pulmonary hypertension in some patients. Drugs like Viagra have been previously shown to inhibit PDE5, but further research was necessary to understand where or how this was occurring.
This study, led by Prof. Donald Maurice of Queen's College focused on the relationship between Viagra and the levels of PDE5 inhibition in cells. They showed that, within each cell, several pools of the PDE5 enzyme may exist. However, only one of these pools might regulate platelet activation. By targeting each pool, it may be possible to revamp Viagra's use to regulate clotting in the blood, helping prevent heart attacks and strokes. "Understanding how the cell works should allow us to affect the activity of enzymes in one neighborhood -- and leave alone their 'identical twins' in a different neighborhood in that cell," says Ms. Wilson, lead author on the study.
The authors note the potential that arises from these developments, both in basic and clinical science. "As scientists, we're excited about this discovery because it's a fundamentally new approach to regulating what enzymes do in cells," states Dr. Maurice. "The fact that it also offers a potentially novel use of a drug already widely in use for other applications is an unexpected bonus." Ms. Wilson continues, hopeful for the potential application of this new knowledge: "The idea is to use a PDE5 inhibitor such as Viagra selectively to inhibit platelet function. We now know that not all the enzymes in the cell are doing the same job. Just like in real estate, it's all about the location!"
http://www.medicalnewstoday.com/articles/119416.php 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 Viagra Shows New Potential To Prevent Clots
伟哥显示出预防血栓的潜力
The cellular response to Viagra may be harnessed to help create new anticoagulant therapies, according to an article released on August 26, 2008 in the Proceedings of the National Academy of Sciences (PNAS.)
据PNAS 2008年8月26日发表的一篇论文报告，细胞对伟哥的应答可能被用于帮助创造新的抗凝治疗（药物）。
The enzyme PDE5 is known to modulate platelet activity. Normally, platelets exist in the blood and have an integral role in blood clotting. However, when patient have certain biomedical devices implanted, such as stents, which are installed in the arteries to maintain blood flow through them, the foreign materials of the devices , are recognized by the body and platelets often clot to them. If too many clot, this can block blood flow, potentially inducing a stroke or heart attack.
已知PDE5酶能调节血小板活性。一般情况下，血小板存在于血液中并参与血液凝固的全过程。然而，当患者被植入一定的生物医学装置时，比如被植入动脉内保持血流通畅的支架就是一个异物装置，它们就会被机体认识并且血小板在其上面凝结成血栓。如果血拴太多的话，就有可能阻碍血流通过，并有潜在的可能导致中风和心脏病发作。
While Viagra is most famous for its use in treatment of erectile dysfunction, it was initially targeted as a drug for the cardiovascular system as a whole and is also used to treat pulmonary hypertension in some patients. Drugs like Viagra have been previously shown to inhibit PDE5, but further research was necessary to understand where or how this was occurring.
而伟哥是被用于治疗勃起功能障碍的最著名的药物，他最初是被用于治疗心血管系统疾病的，同时也用于治疗一些患者的肺动脉高压。伟哥类的药物早前的研究就显示能抑制PDE5酶,但进一步了解它存在的部位并如何起作用的研究显是必要的。
This study, led by Prof. Donald Maurice of Queen's College focused on the relationship between Viagra and the levels of PDE5 inhibition in cells. They showed that, within each cell, several pools of the PDE5 enzyme may exist. However, only one of these pools might regulate platelet activation. By targeting each pool, it may be possible to revamp Viagra's use to regulate clotting in the blood, helping prevent heart attacks and strokes. "Understanding how the cell works should allow us to affect the activity of enzymes in one neighborhood -- and leave alone their 'identical twins' in a different neighborhood in that cell," says Ms. Wilson, lead author on the study.
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作者:admin@医学,生命科学 2011-09-08 17:11
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