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【文摘发布】2型糖尿病与帕金森病风险
Author：Hu G, Jousilahti P, Bidel S, Antikainen R, Tuomilehto J.
Resource: Diabetes Care. 2007 Apr;30(4):842-7.
Abstract：OBJECTIVE: To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. RESEARCH DESIGN AND METHODS: We prospectively followed 51,552 Finnish men and women 25-74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements. Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease associated with the history of type 2 diabetes were estimated. RESULTS: During a mean follow-up period of 18.0 years, 324 men and 309 women developed incident Parkinson's disease. Age- and study year-adjusted hazard ratios of incident Parkinson's disease among subjects with type 2 diabetes, compared with those without it, were 1.80 (95% CI 1.03-3.15) in men, 1.93 (1.05-3.53) in women, and 1.85 (1.23-2.80) in men and women combined (adjusted also for sex). Further adjustment for BMI, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, alcohol drinking, and coffee and tea consumption affected the results only slightly. The multivariate adjusted association between type 2 diabetes and the risk of Parkinson's disease was also confirmed in stratified subgroup analysis. CONCLUSIONS: These data suggest that type 2 diabetes is associated with an increased risk of Parkinson's disease. Surveillance bias might account for higher rates in diabetes. The mechanism behind this association between diabetes and Parkinson's disease is not known.
PMID: 17251276 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领 Title：Type 2 diabetes and the risk of Parkinson's disease.2型糖尿病和帕金森病的风险
Author：Hu G, Jousilahti P, Bidel S, Antikainen R, Tuomilehto J.
Resource: Diabetes Care. 2007 Apr;30(4):842-7.
Abstract：OBJECTIVE: To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. 目的：评价2型糖尿病是否是帕金森病的一个危险因子。
RESEARCH DESIGN AND METHODS: We prospectively followed 51,552 Finnish men and women 25-74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements. Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease 校对一下，供参考：
incident Parkinson's disease 校正了年龄和随访年限后， 2型糖尿病患者伴发帕金森病，与非2型糖尿病患者相比，风险比在男性中为1.80（95％置信区间为1.03-3.15），在女性中为1.93（95％置信区间1.05-3.53），在男性和女性组合（同时进行性别校正后）中为1.85（95％置信区间为1.23-2.80）。
监督偏倚对糖尿病患者中帕金森病患病率增加有一定影响.
在自己的译文中，这两句自己觉得实在是无从下手，不是很理解意思。
谢谢cplamst战友。 谢谢各位前辈的编译 不错不错,非常感谢,有机会向各位请教 文摘编译格式请参照：
http://www.dxy.cn/bbs/post/view?bid=116&id=8600034&sty=1&tpg=1&age=0 [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-08-12 05:31
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