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(abstract)
The early genetic pathway triggering the pathogenesis of coronary artery disease
(CAD) and myocardial infarction (MI) remain largely unknown. Here, we describe
an autosomal dominant form of CAD/MI (adCAD1) that is caused by the deletion
of seven amino acids in transcription factor MEF2A. The deletion disrupts nuclear
localization of MEF2A, reduces MEF2A-mediated transcription activation, and abolishes
synergistic activation by MEF2A and by the transcription factor GATA-1 through
a dominant-negative mechanism. The MEF2A protein demonstrates strong expression
in the endothelium of coronary arteries. These results identify a pathogenic
gene for a familial vascular disease with features of CAD and implicate the
MEF2A signaling pathway in the pathogenesis of CAD/MI.
full-text:http://www.library.imicams.ac.cn/sars_daily/031217/03121701.pdf [标签:content1][标签:content2]
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作者:admin@医学,生命科学 2011-07-30 05:14
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