主页 > 医学信息 >
血小板不仅有促凝作用，且在炎症反应中起重要
source:Blood. 2004 May 6
Human bone marrow megakaryocytes and platelets express PPAR{gamma} and PPAR{gamma} agonists blunt platelet release of CD40 ligand and thromboxanes.
Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP.
Biochemistry, Hacettepe University, Ankara, Turkey; Environmental Medicine, Microbiology and Immunology, and the Lung Biology and Disease Program, University of Rochester, Rochester, NY, USA.
Peroxisome Proliferator Activated Receptor gamma (PPARgamma) is a ligand-activated transcription factor important in lipid metabolism, diabetes, and inflammation. We evaluated whether human platelets and megakaryocytes express PPARgamma and whether PPARgamma agonists influence platelet release of bioactive mediators. Although PPARgamma is mainly considered a nuclear receptor, we show that enucleate platelets highly express PPARgamma protein as shown by western blotting, flow cytometry, and immunocytochemistry. Meg-01 megakaryocyte cells and human bone marrow megakaryocytes also express PPARgamma. Platelet and Meg-01 PPARgamma bound the PPARgamma DNA consensus sequence and this was enhanced by PPARgamma agonists. Platelets are not only essential for clotting, but have an emerging role in inflammation in part due to their release or production of the pro-inflammatory and pro-atherogenic mediators CD40 ligand (L) and thromboxanes (TX). Platelet incubation with a natural PPARgamma agonist, 15d-PGJ2, or with a potent synthetic PPARgamma ligand, rosiglitazone, prevented thrombin-induced CD40L surface expression and release of CD40L and TXB2. 15d-PGJ2 also inhibited platelet aggregation and ATP release. Our results show that human platelets express PPARgamma and that PPARgamma agonists such as the thiazolidinedione class of anti-diabetic drugs have a new target cell, the platelet. This may represent a novel mechanism for treatment of inflammation, thrombosis and vascular disease in high-risk patients. 血小板表达TLRs，TLRs先天免疫系统的重要的识别分子，表明了血小板的免疫反应的作用。 [标签:content1][标签:content2]
阅读本文的人还阅读：
作者:admin@医学,生命科学 2011-04-15 05:14
医学,生命科学网