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血小板不仅有促凝作用,且在炎症反应中起重要

血小板和巨核细核细胞表达PPAR-γ(Peroxisome Proliferator Activated Receptor gamma),PPAR-γ主要被认为是一种配体活化的核受体转录因子,主要在有核细胞表达,在脂代谢、糖尿病及炎症反应中起重要作用。而Akbiyik等的研究发现,血小板和巨核细胞也表达PPAR-γ,且PPAR-γ受体激动剂罗格列酮(降糖药)可活化血小板PPAR-γ因子,促使其结合PPAR-γ的DNA共同序列,抑制血小板产生或释放促炎介质CD40受体和血栓素B2(thromboxanes B2, TXB2),同时也抑制血小板聚集和释放ATP。

source:Blood. 2004 May 6

Human bone marrow megakaryocytes and platelets express PPAR{gamma} and PPAR{gamma} agonists blunt platelet release of CD40 ligand and thromboxanes.

Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP.

Biochemistry, Hacettepe University, Ankara, Turkey; Environmental Medicine, Microbiology and Immunology, and the Lung Biology and Disease Program, University of Rochester, Rochester, NY, USA.

Peroxisome Proliferator Activated Receptor gamma (PPARgamma) is a ligand-activated transcription factor important in lipid metabolism, diabetes, and inflammation. We evaluated whether human platelets and megakaryocytes express PPARgamma and whether PPARgamma agonists influence platelet release of bioactive mediators. Although PPARgamma is mainly considered a nuclear receptor, we show that enucleate platelets highly express PPARgamma protein as shown by western blotting, flow cytometry, and immunocytochemistry. Meg-01 megakaryocyte cells and human bone marrow megakaryocytes also express PPARgamma. Platelet and Meg-01 PPARgamma bound the PPARgamma DNA consensus sequence and this was enhanced by PPARgamma agonists. Platelets are not only essential for clotting, but have an emerging role in inflammation in part due to their release or production of the pro-inflammatory and pro-atherogenic mediators CD40 ligand (L) and thromboxanes (TX). Platelet incubation with a natural PPARgamma agonist, 15d-PGJ2, or with a potent synthetic PPARgamma ligand, rosiglitazone, prevented thrombin-induced CD40L surface expression and release of CD40L and TXB2. 15d-PGJ2 also inhibited platelet aggregation and ATP release. Our results show that human platelets express PPARgamma and that PPARgamma agonists such as the thiazolidinedione class of anti-diabetic drugs have a new target cell, the platelet. This may represent a novel mechanism for treatment of inflammation, thrombosis and vascular disease in high-risk patients. 血小板表达TLRs,TLRs先天免疫系统的重要的识别分子,表明了血小板的免疫反应的作用。 [标签:content1][标签:content2]

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作者:admin@医学,生命科学    2011-04-15 05:14
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