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【文摘发布】1型糖尿病血糖标化后替米沙坦在进
DOI: 10.2337/dc07-0318
TITLE: Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes
AUTHOR: Antonio Ceriello, Ludovica Piconi, Katerine Esposito and Dario Giugliano
ABSTRACT
Background:Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function, by increased oxidative stress, even when glycemia is normalized.
Methods and Results: In this study 36 type 1 diabetic patients and 12 controls were enrolled. The diabetic patients were divided in three groups. The first group was treated for 24h with insulin, achieving a near-normalization of glycemia. At the 12 h of this treatment vitamin C was added for the remaining 12h. The second group was treated for 24h with vitamin C. At the 12 h of this treatment insulin was started, achieving a near-normalization of glycemia for the remaining 12h. The third group was treated for 24h with both vitamin C and insulin, achieving near normalization of glycemia. The same protocols were run after 1 month of Telmisartan or placebo. Neither normalization of glycemia or vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. Combining insulin and vitamin C normalized endothelial dysfunction and decreased oxidative stress to normal level. Telmisartan significantly improved basal endothelial function and decreased nitrotyrosine plasma levels. In patients treated with Telmisartan a near normalization of both flow mediated vasodilation and oxidative stress was achieved when glycemia was normalized, while adding vitamin C infusion did not show further effect on endothelial function or nitrotyrosine plasma levels.
Conclusions:These data indicate that combining the normalization of glycemia with an antioxidant can normalize endothelial function in type 1 diabetic patients and that Telmisartan works as antioxidant as vitamin C. 本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。 RESOURCE Diabetes Care Publish Ahead of Print published online ahead of print April 24, 2007
资料来源：糖尿病关怀的资料发表于2007年4月24联机出版的在线文章
DOI数字化对象识别符: 10.2337/dc07-0318
AUTHOR作者: Antonio Ceriello, Ludovica Piconi, Katerine Esposito and Dario Giugliano
TITLE Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes
标题：Ⅰ型糖尿病血糖标化后替米沙坦在进一步改善内皮功能失调方面与维生素C作用相同
ABSTRACT摘要
Background:Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function by increased oxidative stress, even when glycemia is normalized
背景：在增加氧化压力的情况下，即使当血糖指标正常化的时候，长期维持药物治疗的Ⅰ型糖尿病患者会因血糖过多引起内皮功能的永久性改变。
Methods and Results方法和结果
In this study 36 type 1 diabetic patients and 12 controls were enrolled. The diabetic patients were divided in three groups.
在这项研究中，共计36例Ⅰ型糖尿病患者被随机分为三组，每组12名，分别给予不同的治疗方案进行试验。
The first group was treated for 24h with insulin, achieving a near-normalization of glycemia. At the 12 h of this treatment vitamin C was added for the remaining 12h.
第一组采取24h用胰岛素处理，取得血糖各项指标接近标准化，同时，在本方案中的前12h不给予而后12h给予维生素C处理的方式。
The second group was treated for 24h with vitamin C. At the 12 h of this treatment insulin was started, achieving a near-normalization of glycemia for the remaining 12h.
第二组采取24h用维生素C处理，前12h不给予而后12h给予胰岛素处理的方式，也取得血糖各项指标接近标准化。
The third group was treated for 24h with both vitamin C and insulin, achieving near normalization of glycemia.
第三组采取24h同时给予维生素C和胰岛素处理，取得血糖各项指标接近标准化。
The same protocols were run after 1 month of Telmisartan or placebo.
在替米沙坦或者安慰剂的1个月的给药治疗采取上述同样的方案进行试验。
Neither normalization of glycemia or vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. Combining insulin and vitamin C normalized endothelial dysfunction and decreased oxidative stress to normal level.
没有一个血糖标准化或者单独维生素C处理能使内皮机能障碍或者氧化的压力趋于正常化，合并胰岛素和维生素C使内皮的机能障碍正常化和有助于减少氧化的压力.
Telmisartan significantly improved basal endothelial function and decreased nitrotyrosine plasma levels. In patients treated with Telmisartan a near normalization of both flow mediated
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作者:admin@医学,生命科学 2011-03-31 05:11
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